Tulobuterol

Tulobuterol (INN) is a long-acting beta2-adrenergic receptor agonist, marketed in Japan as a transdermal patch under the name Hokunalin tape (ホクナリンテープ).

Adrenergics
Receptor ligands
α1
  • Agonists: 5-FNE
  • 6-FNE
  • Amidephrine
  • Anisodamine
  • Anisodine
  • Cirazoline
  • Dipivefrine
  • Dopamine
  • Ephedrine
  • Epinephrine
  • Etilefrine
  • Ethylnorepinephrine
  • Indanidine
  • Levonordefrin
  • Metaraminol
  • Methoxamine
  • Methyldopa
  • Midodrine
  • Naphazoline
  • Norepinephrine
  • Octopamine
  • Oxymetazoline
  • Phenylephrine
  • Phenylpropanolamine
  • Pseudoephedrine
  • Synephrine
  • Tetrahydrozoline
    Antagonists: Abanoquil
  • Adimolol
  • Ajmalicine
  • Alfuzosin
  • Amosulalol
  • Arotinolol
  • Atiprosin
  • Benoxathian
  • Buflomedil
  • Bunazosin
  • Carvedilol
  • CI-926
  • Corynanthine
  • Dapiprazole
  • DL-017
  • Domesticine
  • Doxazosin
  • Eugenodilol
  • Fenspiride
  • GYKI-12,743
  • GYKI-16,084
  • Indoramin
  • Ketanserin
  • L-765,314
  • Labetalol
  • Mephendioxan
  • Metazosin
  • Monatepil
  • Moxisylyte
  • Naftopidil
  • Nantenine
  • Neldazosin
  • Nicergoline
  • Niguldipine
  • Pelanserin
  • Phendioxan
  • Phenoxybenzamine
  • Phentolamine
  • Piperoxan
  • Prazosin
  • Quinazosin
  • Ritanserin
  • RS-97,078
  • SGB-1,534
  • Silodosin
  • SL-89.0591
  • Spiperone
  • Talipexole
  • Tamsulosin
  • Terazosin
  • Tibalosin
  • Tiodazosin
  • Tipentosin
  • Tolazoline
  • Trimazosin
  • Upidosin
  • Urapidil
  • Zolertine
*
α2
  • Agonists: (R)-3-Nitrobiphenyline
  • 4-NEMD
  • 6-FNE
  • Amitraz
  • Apraclonidine
  • Brimonidine
  • Cannabivarin
  • Clonidine
  • Detomidine
  • Dexmedetomidine
  • Dihydroergotamine
  • Dipivefrine
  • Dopamine
  • Ephedrine
  • Ergotamine
  • Epinephrine
  • Esproquin
  • Etilefrine
  • Ethylnorepinephrine
  • Guanabenz
  • Guanfacine
  • Guanoxabenz
  • Levonordefrin
  • Lofexidine
  • Medetomidine
  • Methyldopa
  • Mivazerol
  • Naphazoline
  • Norepinephrine
  • Oxymetazoline
  • Phenylpropanolamine
  • Piperoxan
  • Pseudoephedrine
  • Rilmenidine
  • Romifidine
  • Talipexole
  • Tetrahydrozoline
  • Tizanidine
  • Tolonidine
  • Urapidil
  • Xylazine
  • Xylometazoline
    Antagonists: 1-PP
  • Adimolol
  • Aptazapine
  • Atipamezole
  • BRL-44408
  • Buflomedil
  • Cirazoline
  • Efaroxan
  • Esmirtazapine
  • Fenmetozole
  • Fluparoxan
  • GYKI-12,743
  • GYKI-16,084
  • Idazoxan
  • Mianserin
  • Mirtazapine
  • MK-912
  • NAN-190
  • Olanzapine
  • Phentolamine
  • Phenoxybenzamine
  • Piperoxan
  • Piribedil
  • Rauwolscine
  • Rotigotine
  • SB-269,970
  • Setiptiline
  • Spiroxatrine
  • Sunepitron
  • Tolazoline
  • Yohimbine
β
  • Agonists: 2-FNE
  • 5-FNE
  • Amibegron
  • Arbutamine
  • Arformoterol
  • Arotinolol
  • BAAM
  • Bambuterol
  • Befunolol
  • Bitolterol
  • Broxaterol
  • Buphenine
  • Carbuterol
  • Cimaterol
  • Clenbuterol
  • Denopamine
  • Deterenol
  • Dipivefrine
  • Dobutamine
  • Dopamine
  • Dopexamine
  • Ephedrine
  • Epinephrine
  • Etafedrine
  • Etilefrine
  • Ethylnorepinephrine
  • Fenoterol
  • Formoterol
  • Hexoprenaline
  • Higenamine
  • Indacaterol
  • Isoetarine
  • Isoprenaline
  • Isoxsuprine
  • Levonordefrin
  • Levosalbutamol
  • Mabuterol
  • Methoxyphenamine
  • Methyldopa
  • Mirabegron
  • N-Isopropyloctopamine
  • Norepinephrine
  • Orciprenaline
  • Oxyfedrine
  • Phenylpropanolamine
  • Pirbuterol
  • Prenalterol
  • Ractopamine
  • Procaterol
  • Pseudoephedrine
  • Reproterol
  • Rimiterol
  • Ritodrine
  • Salbutamol
  • Salmeterol
  • Solabegron
  • Terbutaline
  • Tretoquinol
  • Tulobuterol
  • Xamoterol
  • Zilpaterol
  • Zinterol
    Antagonists: Acebutolol
  • Adaprolol
  • Adimolol
  • Afurolol
  • Alprenolol
  • Alprenoxime
  • Amosulalol
  • Ancarolol
  • Arnolol
  • Arotinolol
  • Atenolol
  • Befunolol
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bopindolol
  • Bormetolol
  • Bornaprolol
  • Brefonalol
  • Bucindolol
  • Bucumolol
  • Bufetolol
  • Buftiralol
  • Bufuralol
  • Bunitrolol
  • Bunolol
  • Bupranolol
  • Burocrolol
  • Butaxamine
  • Butidrine
  • Butofilolol
  • Capsinolol
  • Carazolol
  • Carpindolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Cetamolol
  • Cicloprolol
  • Cinamolol
  • Cloranolol
  • Cyanopindolol
  • Dalbraminol
  • Dexpropranolol
  • Diacetolol
  • Dichloroisoprenaline
  • Dihydroalprenolol
  • Dilevalol
  • Diprafenone
  • Draquinolol
  • Dropranolol
  • Ecastolol
  • Epanolol
  • Ericolol
  • Ersentilide
  • Esatenolol
  • Esmolol
  • Esprolol
  • Eugenodilol
  • Exaprolol
  • Falintolol
  • Flestolol
  • Flusoxolol
  • Hydroxycarteolol
  • Hydroxytertatolol
  • ICI-118,551
  • Idropranolol
  • Indenolol
  • Indopanolol
  • Iodocyanopindolol
  • Iprocrolol
  • Isoxaprolol
  • Isamoltane
  • Labetalol
  • Landiolol
  • Levobetaxolol
  • Levobunolol
  • Levocicloprolol
  • Levomoprolol
  • Medroxalol
  • Mepindolol
  • Metalol
  • Metipranolol
  • Metoprolol
  • Moprolol
  • Nadolol
  • Nadoxolol
  • Nafetolol
  • Nebivolol
  • Neraminol
  • Nifenalol
  • Nipradilol
  • Oberadilol
  • Oxprenolol
  • Pacrinolol
  • Pafenolol
  • Pamatolol
  • Pargolol
  • Parodilol
  • Penbutolol
  • Penirolol
  • PhQA-33
  • Pindolol
  • Pirepolol
  • Practolol
  • Primidolol
  • Procinolol
  • Pronethalol
  • Propafenone
  • Propranolol
  • Ridazolol
  • Ronactolol
  • Soquinolol
  • Sotalol
  • Spirendolol
  • SR 59230A
  • Sulfinalol
  • TA-2005
  • Talinolol
  • Tazolol
  • Teoprolol
  • Tertatolol
  • Terthianolol
  • Tienoxolol
  • Tilisolol
  • Timolol
  • Tiprenolol
  • Tolamolol
  • Toliprolol
  • Tribendilol
  • Trigevolol
  • Xibenolol
  • Xipranolol
Reuptake inhibitors
NET
  • Selective norepinephrine reuptake inhibitors: Amedalin
  • Atomoxetine (Tomoxetine)
  • Ciclazindol
  • Daledalin
  • Edivoxetine
  • Esreboxetine
  • Lortalamine
  • Mazindol
  • Nisoxetine
  • Reboxetine
  • Talopram
  • Talsupram
  • Tandamine
  • Viloxazine; Norepinephrine-dopamine reuptake inhibitors: Amineptine
  • Bupropion (Amfebutamone)
  • Fencamine
  • Fencamfamine
  • Lefetamine
  • Levophacetoperane
  • LR-5182
  • Manifaxine
  • Methylphenidate
  • Nomifensine
  • O-2172
  • Radafaxine; Serotonin-norepinephrine reuptake inhibitors: Bicifadine
  • Desvenlafaxine
  • Duloxetine
  • Eclanamine
  • Levomilnacipran
  • Milnacipran
  • Sibutramine
  • Venlafaxine; Serotonin-norepinephrine-dopamine reuptake inhibitors: Brasofensine
  • Diclofensine
  • DOV-102,677
  • DOV-21,947
  • DOV-216,303
  • JNJ-7925476
  • JZ-IV-10
  • Methylnaphthidate
  • Naphyrone
  • NS-2359
  • PRC200-SS
  • SEP-225,289
  • SEP-227,162
  • Tesofensine; Tricyclic antidepressants: Amitriptyline
  • Butriptyline
  • Cianopramine
  • Clomipramine
  • Desipramine
  • Dosulepin
  • Doxepin
  • Imipramine
  • Lofepramine
  • melitracen
  • Nortriptyline
  • Protriptyline
  • Trimipramine; Tetracyclic antidepressants: Amoxapine
  • Maprotiline
  • Mianserin
  • Oxaprotiline
  • Setiptiline; Others: Cocaine
  • CP-39,332
  • Ethanol
  • EXP-561
  • Fezolamine
  • Ginkgo biloba
  • Indeloxazine
  • Nefazodone
  • Nefopam
  • Pridefrine
  • Tapentadol
  • Tedatioxetine
  • Teniloxazine
  • Tofenacin
  • Tramadol
  • Ziprasidone
VMAT
  • Ibogaine
  • Reserpine
  • Tetrabenazine
Releasing agents
  • Morpholines: Fenbutrazate
  • Fenmetramide
  • Morazone
  • Phendimetrazine
  • Phenmetrazine
  • Pseudophenmetrazine; Oxazolines: 4-MAR
  • Aminorex
  • Clominorex
  • Cyclazodone
  • Fenozolone
  • Fluminorex
  • Pemoline
  • Thozalinone; Phenethylamines (also amphetamines, cathinones, etc): 2-OH-PEA
  • 4-CAB
  • 4-FA
  • 4-FMA
  • 4-MA
  • 4-MMA
  • Alfetamine
  • Amfecloral
  • Amfepentorex
  • Amfepramone
  • Amphetamine (Dextroamphetamine
  • Levoamphetamine)
  • Amphetaminil
  • β-Me-PEA
  • BDB
  • Benzphetamine
  • BOH
  • Buphedrone
  • Butylone
  • Cathine
  • Cathinone
  • Clobenzorex
  • Clortermine
  • Dimethylamphetamine
  • Dimethylcathinone
  • DMA
  • DMMA
  • EBDB
  • Ephedrine
  • Ethcathinone
  • Ethylone
  • Etilamfetamine
  • Famprofazone
  • Fenethylline
  • Fenproporex
  • Flephedrone
  • Fludorex
  • Furfenorex
  • Hordenine
  • Hydroxyamphetamine
  • IAP
  • IMP
  • Iofetamine
  • Lisdexamfetamine
  • Lophophine
  • MBDB
  • MDA
  • MDEA
  • MDMA
  • MDMPEA
  • MDOH
  • MDPEA
  • Mefenorex
  • Mephedrone
  • Mephentermine
  • Methamphetamine (Dextromethamphetamine
  • Levomethamphetamine)
  • Methcathinone
  • Methedrone
  • Methylone
  • Naphthylisopropylamine
  • Ortetamine
  • pBA
  • pCA
  • Pentorex
  • Phenethylamine
  • Pholedrine
  • Phenpromethamine
  • Phentermine
  • Phenylpropanolamine
  • pIA
  • Prenylamine
  • Propylamphetamine
  • Pseudoephedrine
  • Selegiline (also -Deprenyl)
  • Tiflorex
  • Tyramine
  • Xylopropamine
  • Zylofuramine; Piperazines: 2C-B-BZP
  • BZP
  • MBZP
  • mCPP
  • MDBZP
  • MeOPP
  • pFPP; Others: 2-ADN
  • 2-AI
  • 2-AT
  • 2-BP
  • 4-BP
  • 5-IAI
  • Clofenciclan
  • Cyclopentamine
  • Cypenamine
  • Cyprodenate
  • Feprosidnine
  • Gilutensin
  • Heptaminol
  • Hexacyclonate
  • Indanorex
  • Isometheptene
  • Methylhexanamine
  • Octodrine
  • Phthalimidopropiophenone
  • Propylhexedrine (Levopropylhexedrine)
  • Tuaminoheptane
Enzyme inhibitors
Anabolism
PAH
  • 3,4-Dihydroxystyrene
TH
  • 3-Iodotyrosine
  • Aquayamycin
  • Bulbocapnine
  • Metirosine
  • Oudenone
AAAD
  • Benserazide
  • Carbidopa
  • DFMD
  • Genistein
  • Methyldopa
DBH
  • Bupicomide
  • Disulfiram
  • Dopastin
  • Fusaric acid
  • Nepicastat
  • Phenopicolinic acid
  • Tropolone
PNMT
  • CGS-19281A
  • SKF-64139
  • SKF-7698
Catabolism
MAO
  • Nonselective: Benmoxin
  • Caroxazone
  • Echinopsidine
  • Furazolidone
  • Hydralazine
  • Indantadol
  • Iproclozide
  • Iproniazid
  • Isocarboxazid
  • Isoniazid
  • Linezolid
  • Mebanazine
  • Metfendrazine
  • Nialamide
  • Octamoxin
  • Paraxazone
  • Phenelzine
  • Pheniprazine
  • Phenoxypropazine
  • Pivalylbenzhydrazine
  • Procarbazine
  • Safrazine
  • Tranylcypromine; MAO-A selective: Amiflamine
  • Bazinaprine
  • Befloxatone
  • Befol
  • Brofaromine
  • Cimoxatone
  • Clorgiline
  • Esuprone
  • Harmala alkaloids (Harmine,
  • Harmaline
  • Tetrahydroharmine
  • Harman
  • Norharman, etc)
  • Methylene blue
  • Metralindole
  • Minaprine
  • Moclobemide
  • Pirlindole
  • Sercloremine
  • Tetrindole
  • Toloxatone
  • Tyrima; MAO-B selective:
  • Ladostigil
  • Lazabemide
  • Milacemide
  • Mofegiline
  • Pargyline
  • Rasagiline
  • Safinamide
  • Selegiline (also -Deprenyl)
COMT
  • Entacapone
  • Nitecapone
  • Tolcapone
Others
Precursors
  • L-Phenylalanine → L-Tyrosine → L-DOPA (Levodopa) → Dopamine
  • L-DOPS (Droxidopa)
Cofactors
  • Ferrous Iron (Fe2+)
  • S-Adenosyl-L-Methionine
  • Vitamin B3 (Niacin
  • Nicotinamide → NADPH)
  • Vitamin B6 (Pyridoxine
  • Pyridoxamine
  • Pyridoxal → Pyridoxal Phosphate)
  • Vitamin B9 (Folic acid → Tetrahydrofolic acid)
  • Vitamin C (Ascorbic acid)
  • Zinc (Zn2+)
Others
  • Activity enhancers: BPAP
  • PPAP; Release blockers: Bethanidine
  • Bretylium
  • Guanadrel
  • Guanazodine
  • Guanclofine
  • Guanethidine
  • Guanoxan; Toxins: 6-OHDA
List of adrenergic drugs
Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants
Short acting β2-agonists
  • Bitolterol
  • Carbuterol
  • Fenoterol
  • Pirbuterol
  • Procaterol
  • Reproterol
  • Rimiterol
  • Salbutamol#/Levosalbutamol
  • Terbutaline
  • Tulobuterol
Long acting β2-agonists (LABA)
  • Arformoterol
  • Bambuterol
  • Clenbuterol
  • Formoterol
  • Olodaterol
  • Salmeterol
  • Ultra LABA: Indacaterol
other
  • Epinephrine#
  • Hexoprenaline
  • Isoprenaline (Isoproterenol)
  • Orciprenaline (Metaproterenol)
Glucocorticoids
  • Beclometasone#
  • Betamethasone
  • Budesonide
  • Ciclesonide
  • Flunisolide
  • Fluticasone
  • Mometasone
  • Triamcinolone
Anticholinergics/
muscarinic antagonist
  • Aclidinium bromide
  • Glycopyrronium bromide
  • Ipratropium bromide#
  • Oxitropium bromide
  • Tiotropium bromide
Mast cell stabilizers
  • Cromoglicate
  • Nedocromil
Xanthines
  • Doxofylline
  • Enprofylline
  • Theobromine
  • Theophylline/Aminophylline/Choline theophyllinate
Eicosanoid inhibition
Leukotriene antagonists
  • Montelukast
  • Pranlukast
  • Zafirlukast
Lipoxygenase inhibitor
  • Zileuton
Thromboxane receptor antagonists
  • Ramatroban
  • Seratrodast
Combination products
  • Budesonide/formoterol
  • Fluticasone/salmeterol
  • Ipratropium bromide/salbutamol
  • Mometasone/formoterol
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: RES

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)