Tryptophan Operon Leader - Trp RNA-binding Attenuation Protein

Trp RNA-binding Attenuation Protein

The formation of the anti-terminator requires the trp RNA-binding attenuation protein (TRAP protein) in species of Bacillus and related bacteria. This protein is encoded by the MtrB gene. TRAP protein forms an oligomer of 11 subunits, in the presence of tryptophan this binds to section of RNA containing 11 (G/U)AG repeats. This sequence overlaps the anti-terminator loop, thus TRAP-binding preventing formation of the anti-termintor loop. When TRAP is bound the termintor loop forms and the operon is not transcribed.

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