The Tryptophan operon leader is an RNA element found at the 5' of some bacterial tryptophan operons. The leader sequence can assume two different secondary structures known as the terminator and the anti-terminator structure. The leader also codes for very short peptide sequence that is rich in tryptophan. The terminator structure is recognised as a termination signal for RNA polymerase and the operon is not transcribed. This structure forms when the cell has an excess of tryptophan and ribosome movement over the leader transcript is not impeded. When there is a deficiency of the charged tryptophanyl tRNA the ribosome translating the leader peptide stalls and the antiterminator structure can form. This allows RNA polymerase to transcribe the operon.
At least 6 different amino acid operons are known to be regulated by this attenuation.
Read more about Tryptophan Operon Leader: Trp RNA-binding Attenuation Protein, Tryptophan RNA-binding Attenuator Protein Inhibitory Protein
Other articles related to "operon, tryptophan, tryptophan operon leader, leader":
... coli that has a frameshift mutation in the lactose (LacZ) operon, inactivating the proteins needed for utilization of this sugar ... This meant that a cell could grow only if a second mutation occurred in the lactose operon, reversing the effects of the mutation and therefore allowing the enzymes to be synthesized ... When testing for tryptophan revertants (trp− → trp+, i.e ...
... Tryptophan RNA-binding attenuator protein inhibitory protein (Anti-TRAP protein or AT) is a short protein encoded by the rtpA in Bacillus ... Synthesis of anti-TRAP is induced by uncharged tryptophan tRNA ... Anti-TRAP binds to TRAP and inhibits its binding to the tryptophan operator leader ...
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