Trinucleotide Repeat

Some articles on trinucleotide repeat, repeats, repeat:

Trinucleotide Repeat Disorders - Genetics
... Classification of the trinucleotide repeat, and resulting disease status, depends on the number of CAG repeats in Huntington's Disease Repeat count Classification Disease status 40 Full Penetrance Affected ... This is likely explained by the addition of further CAG-repeats in the gene in the progeny of affected individuals ... For example, Huntington's disease occurs when there are more than 35 CAG repeats on the gene coding for the protein HTT ...
Trinucleotide Repeat Disorders - Trinucleotide Repeat Expansion
... Trinucleotide repeat expansion, also known as triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized as a trinucleotide repeat disorder ... Due to the tandem repeats in the DNA sequence and the instability of the sequence in these regions, 'loop out' structures may form during DNA replication while ... on the daughter strand this will result in an increase in the number of repeats ...
Huntingtin - Clinical Significance
... caused by a mutation in the huntingtin gene, where the CAG repeats more than 36 times and is unstable ... These expanded repeats lead to production of a huntingtin protein that contains an abnormally long polyglutamine tract at the N-terminus ... This makes it part of a class of neurodegenerative disorders known as trinucleotide repeat disorders or polyglutamine disorders ...
Trinucleotide Repeat Disorders
... Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by ... The mutation is a subset of unstable microsatellite repeats that occur throughout all genomic sequences ... If the repeat is present in a healthy gene, a dynamic mutation may increase the repeat count and result in a defective gene ...

Famous quotes containing the word repeat:

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