Identifiers Symbols TPH1; TPRH; TRPH External IDs OMIM: 191060 MGI: 98796 HomoloGene: 121565 ChEMBL: 5689 GeneCards: TPH1 Gene EC number

Gene Ontology
Molecular function tryptophan 5-monooxygenase activity
iron ion binding
amino acid binding
Cellular component cytosol
neuron projection
Biological process circadian rhythm
aromatic amino acid family metabolic process
negative regulation of ossification
cellular nitrogen compound metabolic process
response to immobilization stress
serotonin biosynthetic process
small molecule metabolic process
indolalkylamine biosynthetic process
bone remodeling
mammary gland alveolus development
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7166 21990 Ensembl ENSG00000129167 ENSMUSG00000040046 UniProt P17752 P17532 RefSeq (mRNA) NM_004179 NM_001136084 RefSeq (protein) NP_004170 NP_001129556 Location (UCSC) Chr 11:
18.04 – 18.06 Mb Chr 7:
46.65 – 46.67 Mb PubMed search

Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase), also known as TPH1, is an enzyme which in humans is encoded by the TPH1 gene.

Until 2003 it was thought that there only was a single TPH gene, but then a second form was found in the mouse (Tph2), rat and human brain (TPH2) and the original Tph/TPH was then renamed to Tph1/TPH1.

Read more about TPH1:  Function, Clinical Significance, See Also