Thalassemia

Thalassemia (British English: thalassaemia) are forms of inherited autosomal recessive blood disorders that originated in the Mediterranean region. In thalassemia, the disease is caused by the weakening and destruction of red blood cells.

Whilst possessing the ability to cause significant complications, including anaemia, iron overload, bone deformities and cardiovascular illness, thalassemia may confer a degree of protection against malaria, which is or was prevalent in the regions where the trait is common. This selective survival advantage on carriers (known as heterozygous advantage) may be responsible for perpetuating the mutation in populations. In that respect, the various thalassemias resemble another genetic disorder affecting hemoglobin, sickle-cell disease.

Read more about Thalassemia:  Etymology, Epidemiology, Pathophysiology, Cause, Benefits, Complications

Other articles related to "thalassemia":

Alpha-thalassemia - Epidemiology
... distribution of inherited alpha-thalassemia corresponds to areas of malaria exposure, suggesting a protective role for alpha-thalassemia against the ... Thus, alpha-thalassemia is common in sub-Saharan Africa, the Mediterranean Basin, the Middle East, South Asia, and Southeast Asia, and different ... The epidemiology of alpha-thalassemia in the US reflects this global distribution pattern ...
Delta-thalassemia - Relationship To Beta Thalassemia
... The importance of recognizing the existence of delta thalassemia is seen best in cases where it may mask the diagnosis of beta thalassemia trait ... In beta thalassemia, there is an increase in hemoglobin A2, typically in the range of 4-6% (normal is 2-3%) ... However, the co-existence of a delta thalassemia mutation will decrease the value of the hemoglobin A2 into the normal range, thereby obscuring the diagnosis of beta thalassemia ...
Hemoglobin E/β-thalassaemia
... People who have hemoglobin E/β thalassemia have inherited one gene for hemoglobin E from one parent and one gene for β thalassemia from the other parent ... Hemoglobin E/β thalassemia is a severe disease, and it still has no universal cure ... The consequences of hemoglobin E/β thalassemia when it is not treated can be heart failure, the enlargement of the liver, problems in the bones, etc ...
Thalassemia - Complications
... Iron overload People with thalassemia can get an overload of iron in their bodies, either from the disease itself or from frequent blood transfusions ... Without adequate iron chelation therapy, almost all patients with beta-thalassemia will accumulate potentially fatal iron levels ... Infection people with thalassemia have an increased risk of infection ...
Delta-thalassemia
... Delta-thalassemia is a form of thalassemia ... It is associated with HBD ...