TARS (gene)

Identifiers Symbols TARS; ThrRS External IDs OMIM: 187790 MGI: 106314 HomoloGene: 11852 ChEMBL: 3391 GeneCards: TARS Gene EC number 6.1.1.3

Gene Ontology
Molecular function threonine-tRNA ligase activity
ATP binding
protein homodimerization activity
Cellular component cytoplasm
cytosol
actin cytoskeleton
Biological process translation
tRNA aminoacylation for protein translation
threonyl-tRNA aminoacylation
gene expression
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6897 110960 Ensembl ENSG00000113407 ENSMUSG00000022241 UniProt P26639 Q9D0R2 RefSeq (mRNA) NM_001258437 NM_033074 RefSeq (protein) NP_001245366 NP_149065 Location (UCSC) Chr 5:
33.44 – 33.47 Mb Chr 15:
11.38 – 11.4 Mb PubMed search

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS gene.

Aminoacyl tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family