Syndecan - Protein Domains

Protein Domains

The syndecan proteins can contain the following protein domains,

  • A signal sequence;
  • An extracellular domain (ectodomain) of variable length whose sequence is not evolutionary conserved in the various forms of syndecans. The ectodomain contains the sites of attachment of the heparan sulphate glycosaminoglycan side chains;
  • A transmembrane region;
  • A highly conserved cytoplasmic domain of about 30 to 35 residues, which could interact with cytoskeletal proteins.

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