Stem Cell Niche - Examples of Stem Cell Niches - Cancer Stem Cell Niche - Inflammation


The EMT and cancer progression can be triggered also by chronic inflammation. The main roles have molecules (IL-6, IL-8, TNF-α, NFκB, TGF-β, HIF-1α) which can regulate both processes through regulation of downstream signalling that overlapping between EMT and inflammation. The downstream pathways involving in regulation of CSCs are Wnt, SHH, Notch, TGF-β, RTKs-EGF, FGF, IGF, HGF. NFκB regulates the EMT, migration and invasion of CSCs through Slug, Snail and Twist. The activation of NFκB leads to increase not only in production of IL-6, TNF-α and SDF-1 but also in delivery of growth factors. The source of the cytokine production are lymphocytes (TNF-α), Mesenchymal Stem Cells (SDF-1, IL-6, IL8). Interleukin 6 mediates activation of STAT3. The high level of STAT3 was described in isolated CSCs from liver, bone, cervical and brain cancer. The inhibition of STAT3 results in dramatic reduction in their formation. Generally IL-6 contributes a survival advantage to local stem cells and thus facilitates tumorigenesis. SDF-1α secreted from Mesenchymal Stem Cells (MSCs) has important role in homing and maintenance of Hematopoetic Stem Cell (HSC) in bone marrow niche but also in homing and dissemination of CSC.

Read more about this topic:  Stem Cell Niche, Examples of Stem Cell Niches, Cancer Stem Cell Niche

Other articles related to "inflammation":

Systemic Vasculitis - Classification - Small Vessel Vasculitis - Pauci-immune
... Produces granulomatous inflammation of the respiratory tracts and necrotizing, pauci-immune glomerulonephritis ... of nasal septum by granulomatous inflammation) ... nasal or oral inflammation (oral ulcers or purulent/bloody nasal discharge, may be painful) abnormal CXR showing nodules, infiltrates, cavities microscopic hematuria or RBC casts vessel biopsy shows ...
Cicatricial Alopecia - Diagnosis
... of the scalp biopsy, including the type of inflammation present, location and amount of inflammation, and other changes in the scalp, are necessary to diagnose the type of cicatricial alopecia, to ... Signs of scalp inflammation include redness, scaling, and pustules ... signs and only the scalp biopsy demonstrates the active inflammation ...
... Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges ... The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs ... Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord therefore, the condition is classified as a medical emergency ...
Exercise and Inflammation - Signal-to-noise Theory
... Given that localized acute inflammation is a necessary component for muscle growth, and that chronic low-grade inflammation is associated with a ... By keeping the "noise" of chronic inflammation to a minimum, the localized acute inflammatory response signals a stronger anabolic response than could be achieved with higher levels of chronic inflammation ...
Sanctioned Specialisation
... An example pneumonia can be described as a special type of inflammation Inflammation which has_location Lung and this can be further specialised into pneumococcal pneumonia (caused by pneumococcus ...

Famous quotes containing the word inflammation:

    Dreading that climax of all human ills
    The inflammation of his weekly bills.
    George Gordon Noel Byron (1788–1824)

    With sixty staring me in the face, I have developed inflammation of the sentence structure and definite hardening of the paragraphs.
    James Thurber (1894–1961)