Adverse Drug ReactionsSee also: Quinolone#Adverse effects
- In a review of 2081 adult patients participating in a Phase III clinical trial of sparfloxacin in community-acquired, lower respiratory tract infections, sparfloxacin (200- or 400 mg loading dose then 100 or 200 mg daily; i.e. 200/100 mg and 400/200 mg) had a similar incidence of adverse events as the comparator agents (Rubinstein, 1996). The overall rates of drug-related adverse reactions for sparfloxacin 400/200 mg versus comparators and 200/100 mg versus the comparator (amoxycillin/clavulanic acid) were 13.7 versus 17.7%, and 9.5 versus 13.2%, respectively. However, many of these reported reactions were very minor; discontinua- tion of the antibacterial agent because of drug-related adverse reactions occurred in 1.6 versus 1.6%, and 1) versus 1.1%, respectively. Adverse reactions affecting the nervous system were reported in 5.7% of the sparfloxacin group, with insomnia and other sleep disorders the most common events.
- Phototoxicity was noted in 2.0% of sparfloxacin recipients, with the average delay in onset being 6.3 :t 4.5 days (range 1–14 days) after commencing sparfloxacin. Mostly this consisted of erythema on the face and hands which lasted an average of 6.4 :t 4.2 days. The incidence of phototoxicity associated with sparfloxacin appears to be higher than that observed with ciprofloxacin and ofloxacin but less than that reported for fleroxacin, pefloxacin, enoxacin and nalidixic acid.
- Most importantly, features of the hemolytic-uremic syndrome such as that associated with temafloxacin have not been reported.
Read more about this topic: Sparfloxacin
... Drugs function by binding to specific locations on target molecules and causing a certain desired change, such as disabling the target or causing a conformational ... Ideally, a drug should act very specifically and bind only to its target without interfering with other biological functions ... Computer-assisted drug design has the potential to expedite and lower the costs of drug discovery ...
... excretion (ADME) study, using tritium (3H) labelled drug, temazepam was well absorbed and found to have minimal (8%) first pass drug metabolism ... The unchanged drug was 96% bound to plasma proteins ... The blood level decline of the parent drug was biphasic with the short half-life ranging from 0.4-0.6 hours and the terminal half-life from 3.5–18.4 hours (mean 8.8 ...
... Spontaneous reports of adverse drug reactions associated with cinoxacin, as well as other drugs found within the fluoroquinolone class, are repeatedly made on many Internet forums and medication feedback sites ... These adverse drug reactions are easily and likely often misdiagnosed as seizure disorder or regular CNS or psychiatric symptoms and the diagnosis of quinolone toxicity or adverse reaction ... Italian study done in 2008 showed a far greater risk of an adverse reaction occurring with cinoxacin (cinoxacin was related to the highest ROR value) as compared to the other ...
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... is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone ... Food and Drug Administration (FDA) on December 28, 1990 ... Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration ...
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