Protein Import and Integration
The sorting and assembly machinery is required for the assembly of beta barrel proteins, this includes proteins such as the Tom40 import pore and porin.
Like all mitochondrial proteins, beta barrel proteins are transported into the intermembrane space of mitochondria via the translocase of the outer membrane. Following import, beta barrel proteins are transpoted to the SAM complex by chaperone complexes, formed by assembly of the small Tim proteins. The complex formed by the three sorting and assembly machinery subunits (SAM core complex), is responsible for the integration of beta barrel proteins into the outer mitochondrial membrane. Mdm10 is another mitochondrial membrane protein that is responsible for maintaining mitochondrial morphology and distribution. It has been found to interact with the SAM core complex and may play a role in assembling Tom40 into the translocase of the outer membrane.
Read more about this topic: Sorting And Assembly Machinery
Famous quotes containing the words integration, protein and/or import:
“Look back, to slavery, to suffrage, to integration and one thing is clear. Fashions in bigotry come and go. The right thing lasts.”
—Anna Quindlen (b. 1952)
“Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.”
—Alfred Gingold, U.S. humorist. Items From Our Catalogue, Tofu Innersoles, Avon Books (1982)
“Every tree sends its fibres forth in search of the Wild. The cities import it at any price. Men plow and sail for it. From the forest and wilderness come the tonics and barks which brace mankind.”
—Henry David Thoreau (18171862)