SIX1

SIX1

Identifiers Symbols SIX1; BOS3; DFNA23; TIP39 External IDs OMIM: 601205 MGI: 102780 HomoloGene: 4360 GeneCards: SIX1 Gene

Gene Ontology
Molecular function	• DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding • transcription regulatory region DNA binding
Cellular component	• nucleus • transcription factor complex • nucleolus
Biological process	• negative regulation of transcription from RNA polymerase II promoter • ureteric bud development • branching involved in ureteric bud morphogenesis • organ induction • kidney development • outflow tract morphogenesis • transcription, DNA-dependent • regulation of transcription, DNA-dependent • pattern specification process • skeletal muscle tissue development • sensory perception of sound • regulation of synaptic growth at neuromuscular junction • facial nerve morphogenesis • epithelial cell differentiation • thyroid gland development • regulation of protein localization • protein localization to nucleus • aorta morphogenesis • inner ear morphogenesis • middle ear morphogenesis • negative regulation of neuron apoptotic process • regulation of neuron differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • thymus development • generation of neurons • embryonic cranial skeleton morphogenesis • embryonic skeletal system morphogenesis • inner ear development • myoblast migration • pharyngeal system development • otic vesicle development • metanephric mesenchyme development • regulation of branch elongation involved in ureteric bud branching • positive regulation of ureteric bud formation • mesonephric tubule formation • ureter smooth muscle cell differentiation • positive regulation of secondary heart field cardioblast proliferation • cochlea morphogenesis • positive regulation of branching involved in ureteric bud morphogenesis • negative regulation of branching involved in ureteric bud morphogenesis • positive regulation of mesenchymal cell proliferation involved in ureter development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6495 20471 Ensembl ENSG00000126778 ENSMUSG00000051367 UniProt Q15475 Q62231 RefSeq (mRNA) NM_005982 NM_009189 RefSeq (protein) NP_005973 NP_033215 Location (UCSC) Chr 14:
61.11 – 61.12 Mb Chr 12:
73.04 – 73.05 Mb PubMed search

Homeobox protein SIX1 is a protein that in humans is encoded by the SIX1 gene.

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.