Identifiers Symbols SIX1; BOS3; DFNA23; TIP39 External IDs OMIM: 601205 MGI: 102780 HomoloGene: 4360 GeneCards: SIX1 Gene

Gene Ontology
Molecular function DNA binding
chromatin binding
sequence-specific DNA binding transcription factor activity
protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
Cellular component nucleus
transcription factor complex
Biological process negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
organ induction
kidney development
outflow tract morphogenesis
transcription, DNA-dependent
regulation of transcription, DNA-dependent
pattern specification process
skeletal muscle tissue development
sensory perception of sound
regulation of synaptic growth at neuromuscular junction
facial nerve morphogenesis
epithelial cell differentiation
thyroid gland development
regulation of protein localization
protein localization to nucleus
aorta morphogenesis
inner ear morphogenesis
middle ear morphogenesis
negative regulation of neuron apoptotic process
regulation of neuron differentiation
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
thymus development
generation of neurons
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
inner ear development
myoblast migration
pharyngeal system development
otic vesicle development
metanephric mesenchyme development
regulation of branch elongation involved in ureteric bud branching
positive regulation of ureteric bud formation
mesonephric tubule formation
ureter smooth muscle cell differentiation
positive regulation of secondary heart field cardioblast proliferation
cochlea morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
positive regulation of mesenchymal cell proliferation involved in ureter development
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6495 20471 Ensembl ENSG00000126778 ENSMUSG00000051367 UniProt Q15475 Q62231 RefSeq (mRNA) NM_005982 NM_009189 RefSeq (protein) NP_005973 NP_033215 Location (UCSC) Chr 14:
61.11 – 61.12 Mb Chr 12:
73.04 – 73.05 Mb PubMed search

Homeobox protein SIX1 is a protein that in humans is encoded by the SIX1 gene.

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.

Read more about SIX1:  Interactions

Other articles related to "six1":

SIX1 - Interactions
... SIX1 has been shown to interact with EYA1 and MDFI. ...