Securin

Securin is a protein involved in control of the metaphase-anaphase transition and anaphase onset. Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin, produces an abrupt stimulus that induces highly synchronous chromosome separation in anaphase.

Read more about Securin:  Securin and Separase

Other articles related to "securin":

Separase - Regulation
... cohesin through its association with another protein, securin, as well as phosphorylation by the cyclin-CDK complex ... Interestingly, separase cannot function without initially forming the securin-separase complex in most organisms ... This is because securin helps properly fold separase into the functional conformation ...
BUB3 - Role in The Spindle Assembly Checkpoint
... Securin and cyclin B are also stabilized before the anaphase transition by the unattached kinetochores ... The stabilization of cyclin and securin prevent the degradation that would lead to the irreversible and fast separation of the sister chromatids ... before activation of separase at the stage prior to anaphase, securin inhibits the activity of separase and maintains the cohesion complex ...
Role of Securin in The Onset of Anaphase - Network Characteristics
... It is thought that securin integrates multiple regulatory inputs to make separase activation switch-like, resulting in sudden, coordinated anaphase ... for activation of Cdc14 by separase, leading to dephosphorylation and degradation of securin (Figure 3) ... in budding-yeast strains with mutations in the 2 N-terminal securin phosphorylation sites and securin deletion strains ...
CDC20 - Interactions
... The two main targets of the APC are the S/M cyclins and the protein securin ... Securin is a protein that inhibits separase, which in turn inhibits cohesin, a protein that holds sister chromatids together ... Therefore, in order for anaphase to progress, securin must be inhibited so that cohesin can be cleaved by separase ...
MAD2 - Metaphase-to-anaphase Transition
... a ubiquitin-protein ligase that tags the protein, securin, for destruction ... Securin destruction liberates and activates its bound protease partner, separase ... Separase bound to securin remains inhibited however, when inhibition is relieved, activated separase cleaves the cohesin complex which links the sister chromatids together ...