Ribbon Synapse - Mechanism - Endocytosis

Endocytosis

A high amount of endocytosis is necessary due to the large amount of exocytosis during continued neurotransmitter release in ribbon synapses. Synaptic vesicles need to be recycled for further transmission to occur. These vesicles are directly recycled and because of their mobility, quickly replenish the neurotransmitters required for continued release. In cone photoreceptors, the fused membrane is recycled into the synaptic vesicle without pooling of the membrane into the endosomes. Bipolar cells rely on a different mechanism. It involves taking a large portion of the membrane which is endocytosed and gives rise to synaptic vesicles. This mechanism is conserved in hair cells as well.

Read more about this topic:  Ribbon Synapse, Mechanism

Other articles related to "endocytosis":

Cytosis - Endocytosis
... Endocytosis is when a cell absorbs molecules, such as proteins, from outside the cell by engulfing it with the cell membrane ... The two major types of endocytosis are pinocytosis and phagocytosis ... It is an example of fluid phase endocytosis and is usually a continuous process within the cell ...
Cell-penetrating Peptide - Mechanisms of Membrane Translocation - Endocytosis Mediated Translocation
... Endocytosis is the second mechanism liable for cellular internalization ... Endocytosis is the process of cellular ingestion by which the plasma membrane folds inward to bring substances into the cell ... The classification of cellular localization using fluorescence or by endocytosis inhibitors is the basis of most examination ...
Clathrin-mediated Endocytosis
... The major route for endocytosis in most cells, and the best-understood, is that mediated by the molecule clathrin ... two crucial transport steps (i) receptor-mediated and fluid-phase endocytosis from the plasma membrane to early endosome and (ii) transport from the TGN to endosomes ... In endocytosis, the clathrin coat is assembled on the cytoplasmic face of the plasma membrane, forming pits that invaginate to pinch off (scission) and become free CCVs ...
Ap180
... AP180 is a protein that plays an important role in clathrin-mediated endocytosis of synaptic vesicles ... The C-terminus of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis ... More information is found on endocytosis.org ...