RET Proto-oncogene

RET Proto-oncogene

Identifiers Symbols RET; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51 External IDs OMIM: 164761 MGI: 97902 HomoloGene: 7517 ChEMBL: 2041 GeneCards: RET Gene EC number 2.7.10.1

Gene Ontology
Molecular function protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor activity
calcium ion binding
protein binding
ATP binding
Cellular component integral to plasma membrane
endosome membrane
Biological process MAPK cascade
ureteric bud development
neural crest cell migration
embryonic epithelial tube formation
protein phosphorylation
homophilic cell adhesion
neuron cell-cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
posterior midgut development
positive regulation of neuron projection development
regulation of cell adhesion
positive regulation of cell migration
membrane protein proteolysis
positive regulation of cell adhesion mediated by integrin
ureter maturation
neuron maturation
positive regulation of transcription, DNA-dependent
response to pain
enteric nervous system development
Peyer's patch morphogenesis
cellular response to retinoic acid
positive regulation of metanephric glomerulus development
lymphocyte migration into lymphoid organs
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5979 19713 Ensembl ENSG00000165731 ENSMUSG00000030110 UniProt P07949 P35546 RefSeq (mRNA) NM_000323 NM_001080780 RefSeq (protein) NP_065681 NP_001074249 Location (UCSC) Chr 10:
43.57 – 43.63 Mb Chr 6:
118.15 – 118.2 Mb PubMed search

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.

Read more about RET Proto-oncogene:  Structure, Kinase Activation, Role of RET Signalling During Development, Clinical Relevance, Disease Database, Interactions

Other articles related to "ret":

Hirschsprung's Disease - Genetic Basis - RET Proto-oncogene
... RET is a gene that codes for proteins that assist cells of the neural crest in their movement through the digestive tract during the development of the embryo ... RET can mutate in many ways and is associated with Down's syndrome ... cases, there is a likelihood that RET is involved heavily in both Hirschprung's disease and Down Syndrome ...
RET Proto-oncogene - Interactions
... RET proto-oncogene has been shown to interact with GRB10, STAT3, DOK5, Grb2, GRB7, DOK1, SHC1 and GDNF family receptor alpha 1 ...