Receptor Activated Solely By A Synthetic Ligand

A receptor activated solely by a synthetic ligand (RASSL) or Designer Receptor Exclusively Activated by Designer Drugs (DREADD), permits spatial and temporal control of G protein signaling in vivo. These systems utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic small molecules ligands, like clozapine-N-oxide, and not to their natural ligand(s).

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Receptor Activated Solely By A Synthetic Ligand - Bibliography
... "Controlling signaling with a specifically designed Gi-coupled receptor." ... Cover Evolving the Lock to Fit the Key to Create a Family of G Protein-coupled Receptors Potently Activated by an Inert Ligand." ...

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