A receptor activated solely by a synthetic ligand (RASSL) or Designer Receptor Exclusively Activated by Designer Drugs (DREADD), permits spatial and temporal control of G protein signaling in vivo. These systems utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic small molecules ligands, like clozapine-N-oxide, and not to their natural ligand(s).
Read more about Receptor Activated Solely By A Synthetic Ligand: Mechanism, Uses, History, Bibliography
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