Protein Design

Protein design is the design of new protein molecules, either from scratch or by making calculated variations on a known structure. The use of rational design techniques for proteins is a major aspect of protein engineering.

The design of minimalist computer models of proteins (lattice proteins), and the secondary structural modification of real proteins, began in the mid-1990s. The de novo design of real proteins became possible shortly afterwards, and in the 21st century it has become a productive field of research. There is great hope that the design of new proteins, small and large, will have applications in medicine and bioengineering (see examples below).

Read more about Protein DesignOverview, Examples of Designed Proteins, Models of Protein Structure and Function Used in Protein Design, Ancestral Sequence Reconstruction, Software

Other articles related to "protein design, protein, proteins, design":

Protein Design - Software
... Iterative Protein Redesign and Optimization ... IPRO redesigns proteins to increase or give specificity to native or novel substrates and cofactors ... This is done by repeatedly randomly perturbing the backbones of the proteins around specified design positions, identifying the lowest energy combination of rotamers ...
Protein Engineering - Rational Design of Proteins
... In rational protein design, the scientist uses detailed knowledge of the structure and function of the protein to make desired changes ... major drawback is that detailed structural knowledge of a protein is often unavailable, and even when it is available, it can be extremely difficult to predict the effects of various ... Computational protein design algorithms seek to identify novel amino acid sequences that are low in energy when folded to the pre-specified target structure ...
Rosetta@home - Project Significance
... Further information Protein structure prediction, Protein docking, Protein design With the proliferation of genome sequencing projects, scientists can infer ... To better understand a protein's function and aid in rational drug design, scientists need to know the protein's three-dimensional tertiary structure ... Protein 3D structures are currently determined experimentally through X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy ...
Dead-end Elimination - Protein Design
... That is, the sequence of the protein was assumed to be fixed ... This allows a novel sequence to be designed onto a given protein backbone ... A short zinc finger protein fold has been redesigned this way ...

Famous quotes containing the words design and/or protein:

    You can make as good a design out of an American turkey as a Japanese out of his native stork.
    —For the State of Illinois, U.S. public relief program (1935-1943)

    Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.
    Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)