Glycoprotein Ib-IX-V Complex (GPIb-IX-V)
This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. Each of them has a variable number of leucine-rich repeats. GPIbα and GPIbβ are linked by disulfide bridges, while the GPV and GPIX associate non-covalently with the complex. GPIbα subunit bears the binding site for von Willebrand factor (vWF), α thrombin, leukocyte integrin αMβ2 and P-selectin. The binding between GPIbα and vWF mediates the capture of platelets to the injured vascular wall. The deficiency in glycoprotein Ib-IX-V complex synthesis leads to Bernard-Soulier syndrome.
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“Instead of seeing society as a collection of clearly defined interest groups, society must be reconceptualized as a complex network of groups of interacting individuals whose membership and communication patterns are seldom confined to one such group alone.”
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