Interactions of The Platelet Surface Glycoproteins
The binding of von Willebrand factor (vWF) results in conformational changes within the GPIb-IX-V complex. In consequence, this complex activates GPIIb / IIIa membrane glycoproteins allowing them to bind fibrinogen. Fibrinogen molecules then interconnect the platelets serving as the basis for platelet aggregation. In the absence of fibrinogen, the platelets are joined by vWF due to its ability to bind the activated GPIIb / IIIa complex.
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