Neurogenic inflammation is inflammation arising from the local release from afferent neurons of inflammatory mediators such as Substance P and Calcitonin Gene-Related Peptide (CGRP).
This process appears to play an important role in the pathogenesis of numerous diseases including psoriasis, asthma, fibromyalgia, eczema, rosacea, dystonia, multiple chemical sensitivity, and migraine.
In migraine, stimulation of the trigeminal nerve causes neurogenic inflammation via release of neuropeptides including Substance P, nitric oxide, vasoactive intestinal polypeptide, 5-HT, Neurokinin A and CGRP. leading to a "sterile neurogenic inflammation."
Other articles related to "neurogenic inflammation, inflammation":
... Magnesium deficiency causes neurogenic inflammation in a rat model ... P is a key in the path from magnesium deficiency to the subsequent cascade of neuro-inflammation ... intake, even at levels not uncommon in humans, not only triggers neurogenic inflammation but may also be a risk factor for osteoporosis ...
Famous quotes containing the word inflammation:
“With sixty staring me in the face, I have developed inflammation of the sentence structure and definite hardening of the paragraphs.”
—James Thurber (18941961)