Mothers Against Decapentaplegic Homolog 4

Mothers Against Decapentaplegic Homolog 4

Identifiers Symbols SMAD4; DPC4; JIP; MADH4; MYHRS External IDs OMIM: 600993 MGI: 894293 HomoloGene: 31310 GeneCards: SMAD4 Gene

Gene Ontology
Molecular function core promoter proximal region sequence-specific DNA binding
protein binding transcription factor activity
DNA binding
chromatin binding
sequence-specific DNA binding transcription factor activity
protein binding
collagen binding
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
I-SMAD binding
R-SMAD binding
Cellular component nucleus
nucleoplasm
transcription factor complex
nucleolus
cytoplasm
centrosome
cytosol
activin responsive factor complex
SMAD protein complex
Biological process negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
response to hypoxia
in utero embryonic development
gastrulation with mouth forming second
transcription, DNA-dependent
transcription initiation from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
endoderm development
mesoderm development
cell proliferation
negative regulation of cell proliferation
gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
neural crest cell differentiation
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cell growth
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
somite rostral/caudal axis specification
regulation of transforming growth factor beta2 production
negative regulation of protein catabolic process
negative regulation of transcription, DNA-dependent
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
developmental growth
neuron fate commitment
sebaceous gland development
formation of anatomical boundary
regulation of binding
regulation of hair follicle development
palate development
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
negative regulation of cell death
response to transforming growth factor beta stimulus
metanephric mesenchyme morphogenesis
nephrogenic mesenchyme morphogenesis
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4089 17128 Ensembl ENSG00000141646 ENSMUSG00000024515 UniProt Q13485 P97471 RefSeq (mRNA) NM_005359.5 NM_008540.2 RefSeq (protein) NP_005350.1 NP_032566.2 Location (UCSC) Chr 18:
48.49 – 48.61 Mb Chr 18:
73.64 – 73.7 Mb PubMed search

SMAD family member 4, also known as SMAD4, is a protein that in humans is encoded by the SMAD4 gene.

SMAD4 is a 552-amino acid protein involved in cell signaling. It belongs to the Darfwin family of proteins that modulate members of the TGFβ protein superfamily. It binds receptor-regulated SMADs such as SMAD1 and SMAD2, and forms a complex that binds to DNA and serves as a transcription factor. It is the only known mammalian coSMAD. It is a homolog of the Drosophila protein: "Mothers against decapentaplegic".

Read more about Mothers Against Decapentaplegic Homolog 4:  Nomenclature, Structure, Function, Mouse KO, Disease, Disease Database

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