MEF2C

MEF2C

Identifiers Symbols MEF2C; C5DELq14.3; DEL5q14.3 External IDs OMIM: 600662 MGI: 99458 HomoloGene: 31087 GeneCards: MEF2C Gene

Gene Ontology
Molecular function RNA polymerase II regulatory region sequence-specific DNA binding
sequence-specific DNA binding RNA polymerase II transcription factor activity
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
DNA binding
AT DNA binding
sequence-specific DNA binding transcription factor activity
protein binding
activating transcription factor binding
miRNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
Cellular component nucleus
nucleoplasm
nucleolus
cytoplasm
nuclear speck
intracellular membrane-bounded organelle
protein complex
Biological process negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
blood vessel development
osteoblast differentiation
B cell homeostasis
heart looping
endochondral ossification
blood vessel remodeling
chondrocyte differentiation
toll-like receptor signaling pathway
germinal center formation
regulation of germinal center formation
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
primary heart field specification
secondary heart field specification
outflow tract morphogenesis
sinoatrial valve morphogenesis
cardiac ventricle formation
transcription from RNA polymerase II promoter
apoptotic process
humoral immune response
nervous system development
heart development
muscle organ development
skeletal muscle tissue development
muscle cell fate determination
learning or memory
Toll signaling pathway
response to virus
positive regulation of gene expression
negative regulation of gene expression
positive regulation of alkaline phosphatase activity
neural crest cell differentiation
myotube differentiation
neuron differentiation
platelet formation
negative regulation of ossification
melanocyte differentiation
positive regulation of bone mineralization
positive regulation of B cell proliferation
toll-like receptor 1 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
cellular response to drug
cellular response to trichostatin A
B cell proliferation
muscle cell differentiation
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
innate immune response
regulation of megakaryocyte differentiation
positive regulation of myoblast differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
nerve growth factor receptor signaling pathway
positive regulation of skeletal muscle tissue development
neuron development
B cell receptor signaling pathway
smooth muscle cell differentiation
positive regulation of muscle cell differentiation
stress-activated MAPK cascade
ventricular cardiac muscle cell differentiation
regulation of synaptic activity
positive regulation of cardiac muscle cell proliferation
renal tubule morphogenesis
cellular response to lipopolysaccharide
cellular response to calcium ion
cellular response to parathyroid hormone stimulus
cellular response to fluid shear stress
cellular response to transforming growth factor beta stimulus
glomerulus morphogenesis
nephron tubule epithelial cell differentiation
positive regulation of protein homodimerization activity
positive regulation of macrophage apoptotic process
positive regulation of cardiac muscle cell differentiation
positive regulation of behavioral fear response
epithelial cell proliferation involved in renal tubule morphogenesis
positive regulation of skeletal muscle cell differentiation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4208 17260 Ensembl ENSG00000081189 ENSMUSG00000005583 UniProt Q06413 Q8CFN5 RefSeq (mRNA) NM_001131005 NM_001170537 RefSeq (protein) NP_001124477 NP_001164008 Location (UCSC) Chr 5:
88.01 – 88.2 Mb Chr 13:
83.5 – 83.67 Mb PubMed search

Myocyte-specific enhancer factor 2C also known as MADS box transcription enhancer factor 2, polypeptide C is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family.

Read more about MEF2C:  Genomics, Interactions, Biological Significance

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MEF2C - Biological Significance
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