Malate Dehydrogenase 2

Malate Dehydrogenase 2

Identifiers Symbols MDH2; M-MDH; MDH; MGC:3559; MOR1 External IDs OMIM: 154100 MGI: 97050 HomoloGene: 55938 ChEMBL: 5917 GeneCards: MDH2 Gene EC number

Gene Ontology
Molecular function L-malate dehydrogenase activity
protein self-association
malate dehydrogenase (NADP+) activity
Cellular component nucleus
mitochondrial inner membrane
mitochondrial matrix
plasma membrane
Biological process carbohydrate metabolic process
glucose metabolic process
tricarboxylic acid cycle
oxaloacetate metabolic process
malate metabolic process
internal protein amino acid acetylation
NADH metabolic process
cellular carbohydrate metabolic process
small molecule metabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4191 17448 Ensembl ENSG00000146701 ENSMUSG00000019179 UniProt P40926 P08249 RefSeq (mRNA) NM_005918 NM_008617 RefSeq (protein) NP_005909 NP_032643 Location (UCSC) Chr 7:
75.68 – 75.7 Mb Chr 5:
135.78 – 135.79 Mb PubMed search

Malate dehydrogenase 2, NAD (mitochondrial), also known as MDH2, is a protein which in humans is encoded by the MDH2 gene.

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.

Read more about Malate Dehydrogenase 2:  Interactive Pathway Map