Malate Dehydrogenase - Isozymes


Several isozymes of malate dehydrogenase exist. There are two main isoforms in eukaryotic cells. One is found in the mitochondrial matrix, participating as a key enzyme in the citric acid cycle that catalyzes the oxidation of malate. The other is found in the cytoplasm, assisting the malate-aspartate shuttle with exchanging reducing equivalents so that malate can pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes.

Humans and most other mammals express the following two malate dehydrogenases:

malate dehydrogenase 1, NAD (soluble)
Symbol MDH1
Entrez 4190
HUGO 6970
OMIM 154200
RefSeq NM_005917
UniProt P40925
Other data
EC number
Locus Chr. 2 p23
malate dehydrogenase 2, NAD (mitochondrial)
Symbol MDH2
Entrez 4191
HUGO 6971
OMIM 154100
RefSeq NM_005918
UniProt P40926
Other data
EC number
Locus Chr. 7 cen-q22

Read more about this topic:  Malate Dehydrogenase

Other articles related to "isozymes, isozyme":

Distinguishing Isozymes
... Isozymes (and allozymes) are variants of the same enzyme ... differ significantly in their function are unlikely to have been identified as isozymes ... Whilst isozymes may be almost identical in function, they may differ in other ways ...
Aldolase B - Structure - Isozyme Specific Regions
... the majority of the overall structure of the aldolase enzyme is conserved amongst the three isozymes, four regions of the generic aldolase enzyme have been ... Such regions have been denoted isozyme-specific regions (ISR1-4) ... These regions are thought to give isozymes their specificities and structural differences ...
... Isozymes (also known as isoenzymes or more generally as Multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction ... The existence of isozymes permits the fine-tuning of metabolism to meet the particular needs of a given tissue or developmental stage (for example ... In biochemistry, isozymes (or isoenzymes) are isoforms (closely related variants) of enzymes ...
Isozyme - Introduction
... Isozymes were first described by R ... genes and thus represent different loci (described as isozymes) and (2) enzymes that are the product of different alleles of the same gene (described as allozymes) ... Isozymes are usually the result of gene duplication, but can also arise from polyploidisation or nucleic acid hybridization ...