Lusitropy is myocardial relaxation. The increase in cytosolic calcium of cardiomyocytes via increased uptake leads to increased myocardial contractility (positive inotropic effect), but the myocardial relaxation, or lusitropy, decreases. This should not be confused, however, with catecholamine-induced calcium uptake into the sarcoplasmic reticulum, which increases lusitropy.

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Lusitropy - Negative
1) Calcium overload - too much intracellular calcium 2) Reduced rate of calcium removal from myocyte through pumps - if calcium is not removed from the cell quickly enough ... a) Plasma membrane Calcium ATPase (Ca ATPase) - this primary active transporter pumps calcium out of the myocyte between beats b) Sodium-Calcium (Na/Ca) exchanger - this secondary active transporter pumps calcium out of cell between beats 3) Impaired Sarco-Endoplasmic Reticulum Calcium ATPase (SERCA) - this primary active transporter pumps calcium from the cytoplasm of the myocyte into its sarco-endoplasmic reticulum ...