LTP Induction

LTP Induction

The induction of NMDA receptor-dependent long-term potentiation (LTP) in chemical synapses in the brain occurs via a fairly straightforward mechanism. A substantial and rapid rise in calcium ion concentration inside the postsynaptic cell (or more specifically, within the dendritic spine) is most possibly all that is required to induce LTP. But the mechanism of calcium delivery to the postsynaptic cell in inducing LTP is more complicated.

Read more about LTP Induction:  The Role of The AMPA Receptor, The Role of The NMDA Receptor

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LTP Induction - The Role of The NMDA Receptor - Magnesium Blockade
... What makes this magnesium blockade of the NMDAR channel particularly significant in terms of LTP induction is that the block is membrane voltage-dependent ... The basis of this voltage dependence is relatively straightforward ...

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    One might get the impression that I recommend a new methodology which replaces induction by counterinduction and uses a multiplicity of theories, metaphysical views, fairy tales, instead of the customary pair theory/observation. This impression would certainly be mistaken. My intention is not to replace one set of general rules by another such set: my intention is rather to convince the reader that all methodologies, even the most obvious ones, have their limits.
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