Identifiers Symbols LILRB2; CD85D; ILT4; LILRA6; LIR-2; LIR2; MIR-10; MIR10 External IDs OMIM: 604815 HomoloGene: 81741 GeneCards: LILRB2 Gene

Gene Ontology
Molecular function receptor activity
protein binding
protein phosphatase 1 binding
MHC class Ib protein binding
inhibitory MHC class I receptor activity
MHC class I protein binding
eukaryotic cell surface binding
cell adhesion molecule binding
Cellular component extracellular space
plasma membrane
integral to plasma membrane
cell surface
Biological process negative regulation of antigen processing and presentation
positive regulation of T cell tolerance induction
immune response-inhibiting cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
immune response
cellular defense response
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
positive regulation of interleukin-6 production
heterotypic cell-cell adhesion
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of regulatory T cell differentiation
regulation of immune response
negative regulation of calcium ion transport
cellular response to lipopolysaccharide
regulation of dendritic cell differentiation
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10288 n/a Ensembl ENSG00000131042 n/a UniProt Q8N423 n/a RefSeq (mRNA) NM_001080978 n/a RefSeq (protein) NP_001074447 n/a Location (UCSC) Chr 19:
54.78 – 54.79 Mb n/a PubMed search n/a

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Read more about LILRB2:  Interactions

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LILRB2 - Interactions
... LILRB2 has been shown to interact with PTPN6. ...