| Gene Ontology | |
|---|---|
| Molecular function | • protein phosphatase 1 binding • HLA-A specific inhibitory MHC class I receptor activity • HLA-B specific inhibitory MHC class I receptor activity • MHC class I receptor activity • SH2 domain binding • MHC class I protein binding • protein homodimerization activity |
| Cellular component | • cytoplasm • plasma membrane • external side of plasma membrane • integral to membrane |
| Biological process | • negative regulation of T cell mediated cytotoxicity • positive regulation of defense response to virus by host • T cell proliferation involved in immune response • negative regulation of cytokine secretion involved in immune response • immune response-inhibiting cell surface receptor signaling pathway • Fc receptor mediated inhibitory signaling pathway • signal transduction • response to virus • positive regulation of gene expression • negative regulation of serotonin secretion • receptor internalization • interferon-gamma production • negative regulation of interferon-gamma production • negative regulation of mononuclear cell proliferation • negative regulation of interferon-beta secretion • negative regulation of T cell proliferation • negative regulation of tumor necrosis factor biosynthetic process • positive regulation of apoptotic process • negative regulation of interferon-gamma biosynthetic process • negative regulation of cell cycle • negative regulation of endocytosis • positive regulation of cytolysis • positive regulation of transcription from RNA polymerase II promoter • negative regulation of natural killer cell mediated cytotoxicity • negative regulation of alpha-beta T cell activation • regulation of immune response • defense response to virus • negative regulation of calcium ion transport • cellular response to lipopolysaccharide • interferon-gamma secretion • dendritic cell differentiation • negative regulation of dendritic cell apoptotic process • negative regulation of interleukin-10 secretion • negative regulation of interleukin-12 secretion • negative regulation of CD8-positive, alpha-beta T cell activation • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • positive regulation of gamma-delta T cell activation involved in immune response • negative regulation of dendritic cell differentiation • negative regulation of transforming growth factor-beta secretion • negative regulation of osteoclast development |
| Sources: Amigo / QuickGO | |
55.09 – 55.15 Mb
Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.