LILRB1

Identifiers Symbols LILRB1; CD85; CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7 External IDs OMIM: 604811 HomoloGene: 88463 GeneCards: LILRB1 Gene

Gene Ontology
Molecular function protein phosphatase 1 binding
HLA-A specific inhibitory MHC class I receptor activity
HLA-B specific inhibitory MHC class I receptor activity
MHC class I receptor activity
SH2 domain binding
MHC class I protein binding
protein homodimerization activity
Cellular component cytoplasm
plasma membrane
external side of plasma membrane
integral to membrane
Biological process negative regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
T cell proliferation involved in immune response
negative regulation of cytokine secretion involved in immune response
immune response-inhibiting cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
signal transduction
response to virus
positive regulation of gene expression
negative regulation of serotonin secretion
receptor internalization
interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of mononuclear cell proliferation
negative regulation of interferon-beta secretion
negative regulation of T cell proliferation
negative regulation of tumor necrosis factor biosynthetic process
positive regulation of apoptotic process
negative regulation of interferon-gamma biosynthetic process
negative regulation of cell cycle
negative regulation of endocytosis
positive regulation of cytolysis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of natural killer cell mediated cytotoxicity
negative regulation of alpha-beta T cell activation
regulation of immune response
defense response to virus
negative regulation of calcium ion transport
cellular response to lipopolysaccharide
interferon-gamma secretion
dendritic cell differentiation
negative regulation of dendritic cell apoptotic process
negative regulation of interleukin-10 secretion
negative regulation of interleukin-12 secretion
negative regulation of CD8-positive, alpha-beta T cell activation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
positive regulation of gamma-delta T cell activation involved in immune response
negative regulation of dendritic cell differentiation
negative regulation of transforming growth factor-beta secretion
negative regulation of osteoclast development
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10859 n/a Ensembl ENSG00000104972 n/a UniProt Q8NHL6 n/a RefSeq (mRNA) NM_001081637 n/a RefSeq (protein) NP_001075106 n/a Location (UCSC) Chr 19:
55.09 – 55.15 Mb n/a PubMed search n/a

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.