Identifiers Symbols KLC1; KLC; KNS2; KNS2A External IDs OMIM: 600025 MGI: 107978 HomoloGene: 4056 GeneCards: KLC1 Gene

Gene Ontology
Molecular function motor activity
microtubule motor activity
protein binding
Cellular component cytosol
kinesin complex
Biological process microtubule-based movement
blood coagulation
virus-host interaction
antigen processing and presentation of exogenous peptide antigen via MHC class II
stress granule disassembly
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3831 16593 Ensembl ENSG00000126214 ENSMUSG00000021288 UniProt Q07866 D3Z5T6 RefSeq (mRNA) NM_001130107 NM_001025358 RefSeq (protein) NP_001123579 NP_001020531 Location (UCSC) Chr 14:
104.03 – 104.15 Mb Chr 12:
111.76 – 111.81 Mb PubMed search

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.

Read more about KLC1:  Interactions

Other articles related to "klc1":

KLC1 - Interactions
... KLC1 has been shown to interact with MAPK8IP3, KIF5B and KIF5A. ...