Juvenile polyposis syndrome is a syndrome characterized by the appearance of multiple polyps in the gastrointestinal tract, usually in a child, adolescent or young adult. Polyps refers to an abnormal growth arising from a mucous membrane. While the majority of the polyps found in Juvenile Polyposis Syndrome are non-neoplastic, hamartomatous, self-limiting and benign, there is an increased risk of adenocarcinoma.
Solitary juvenile polyps most commonly occur in the rectum and present with rectal bleeding. The World Health Organization criteria for diagnosis of juvenile polyposis syndrome are one of either:
- More than five juvenile polyps in the colon or rectum; or
- Juvenile polyps throughout the gastrointestinal tract; or
- Any number of juvenile polyps in a person with a family history of juvenile polyposis.
... table Disorder name Mutation type Chromosome 1p36 deletion syndrome D 1p36 18p deletion syndrome D 18p 21-hydroxylase deficiency 6p21.3 45,X C X 47,XX,+21 C ...
... People with juvenile polyps may require yearly upper and lower endoscopies with polyp excision and cytology ...
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