Jun D

Jun D

Identifiers Symbols JUND; AP-1 External IDs OMIM: 165162 MGI: 96648 HomoloGene: 3910 GeneCards: JUND Gene

Gene Ontology
Molecular function sequence-specific DNA binding transcription factor activity
protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
Cellular component chromatin
Biological process osteoblast development
transcription, DNA-dependent
regulation of transcription from RNA polymerase II promoter
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to calcium ion
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3727 16478 Ensembl ENSG00000130522 ENSMUSG00000071076 UniProt P17535 P15066 RefSeq (mRNA) NM_005354 NM_010592 RefSeq (protein) NP_005345 NP_034722 Location (UCSC) Chr 19:
18.39 – 18.39 Mb Chr 8:
70.7 – 70.7 Mb PubMed search

Transcription factor jun-D is a protein that in humans is encoded by the JUND gene.

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.

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