Ultimate Fighting Championship
At UFC 78 Lauzon submitted previously undefeated Jason Reinhardt by rear naked choke in the first round. Lauzon quickly took Reinhardt down before moving to the north-south position. Reinhardt rolled, giving Lauzon his back, and Lauzon quickly sunk in the rear naked choke for a quick submission victory.
On April 2, 2008, Kenny Florian defeated Lauzon in the main event of UFC Fight Night 13 by TKO via strikes from mount in the second round. The first round was back and forth as Florian opened up a cut on Lauzon's head with elbows and took his back while Lauzon landed several takedowns and attempted several submissions. Florian opened the second round with a takedown and soon advanced to mount where he landed multiple unanswered strikes until the fight was waved off.
Lauzon defeated Kyle Bradley by TKO (punches) in round two at UFC Fight Night 15. In the first round Bradley connected with a punch and rocked Lauzon. Lauzon managed to recover and continued to trade with Bradley in a close first round. In the second round Lauzon scored a takedown and transitioned quickly into mount before taking Bradley's back. Lauzon landed several punches from this position until the referee stepped in to save Bradley.
Lauzon was scheduled to fight Hermes Franca on February 7, 2009, in the main event for UFC Fight Night 17. However, Franca pulled out of the event with a torn anterior cruciate ligament in his right knee. Jeremy Stephens stepped in as a late replacement. Lauzon defeated Stephens by armbar in the second round.
Lauzon fought Sam Stout on January 2, 2010, at UFC 108 and lost in a very entertaining fight by decision, which also won Fight of the Night.
Lauzon was expected to face Terry Etim on August 28, 2010, at UFC 118, but Etim had to withdraw from the bout due to injury. Lauzon was instead set to fight fellow Ultimate Fighter season 5 castmate Gabe Ruediger. During the UFC 118 weigh-ins Ruediger brought Lauzon a cake that read "Sorry for your loss". Lauzon defeated Ruediger, who is a black belt in Brazilian Jiu-Jitsu, via armbar in 2:01 of round 1 having completely dominated him for the entire fight. According to Joe Rogan, Gabe "was never in it for a second."
Lauzon faced George Sotiropoulos on November 20, 2010, at UFC 123. The fight began with an action-packed first round, that saw Lauzon set the pace. However, by the end of the round, Lauzon began to tire and saw Sotiropoulos began to gain momentum. The second round saw a fatigued and passive Joe Lauzon. After a scramble, Sotiropoulous ended up on top position and torqued a kimura to force the tap-out.
Lauzon faced Curt Warburton on June 26 at UFC on Versus 4. Lauzon defeated Warburton via first round kimura.
Lauzon was briefly linked to a bout with Charles Oliveira on November 19, 2011 at UFC 138. However, Oliveira instead faced Donald Cerrone on August 14, 2011 at UFC Live: Hardy vs. Lytle, replacing an injured Paul Taylor.
Lauzon defeated Melvin Guillard on October 8, 2011 by rear naked choke at UFC 136, earning his fourth Submission of the Night honor and sixth straight UFC Bonus award.
Lauzon faced Anthony Pettis on February 26, 2012 at UFC 144 He lost the fight by KO due to a head kick in 91 seconds.
Lauzon was expected to face Terry Etim on August 4, 2012 at UFC on Fox 4. However, Etim was forced out of the bout with an injury and replaced by Jamie Varner. In a back-and-forth fight that saw both men rocked, Lauzon secured the victory after locking in a triangle choke on Varner at 2:44 of the third round. His performance earned him the Fight of the Night and Submission of the Night honors and a Fight of the Year nomination at the World MMA Awards.
Lauzon was expected to face Gray Maynard on December 29, 2012 at UFC 155. However, Maynard pulled out of the bout citing a knee injury and was replaced by Jim Miller. Miller defeated Lauzon via unanimous decision. The back and forth action earned both participants Fight of the Night honors.
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