Innate Immune System - Innate Immune Evasion

Innate Immune Evasion

Cells of the innate immune system effectively prevent free growth of bacteria within the body; however, many pathogens have evolved mechanisms allowing them to evade the innate immune system.

Evasion strategies that circumvent the innate immune system include intracellular replication, such as in Mycobacterium tuberculosis, or a protective capsule that prevents lysis by complement and by phagocytes, as in salmonella. Bacteroides species are normally mutualistic bacteria, making up a substantial portion of the mammalian gastrointestinal flora. Some species (B. fragilis, for example) are opportunistic pathogens, causing infections of the peritoneal cavity. These species evade the immune system through inhibition of phagocytosis by affecting the receptors that phagocytes use to engulf bacteria or by mimicking host cells so that the immune system does not recognize them as foreign. Staphylococcus aureus inhibits the ability of the phagocyte to respond to chemokine signals. Other organisms such as M. tuberculosis, Streptococcus pyogenes and Bacillus anthracis utilize mechanisms that directly kill the phagocyte.

Bacteria and fungi may also form complex biofilms, providing protection from the cells and proteins of the immune system; recent studies indicate that such biofilms are present in many successful infections, including the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic fibrosis.

Read more about this topic:  Innate Immune System

Other articles related to "innate immune evasion, immune":

Innate Immune Evasion - Evasion of The Innate Immune System By Virus.
... Some viruses are able to evade this immune system, by producing molecules that interfere with IFN production pathway ...
La Jolla Institute For Allergy And Immunology - Research - T Cell Activation
... protein kinase C theta - which may hold the key to controlling immune response ... will allow scientists to design treatments aimed at either boosting an immune response, such as to fight cancer, or to suppress an unwanted immune attack on normal cells, which occurs in ...
Acquired Hemolytic Anemia - Immune
... Immune mediated hemolytic anemia (direct Coombs test is positive) Autoimmune hemolytic anemia Warm antibody autoimmune hemolytic anemia Idiopathic Systemic lupus erythematosus (SLE ... from a non-compatible blood type) Drug induced immune mediated hemolytic anemia Penicillin (high dose) Methyldopa ...
Sickness Behavior - Immune Control
... Lipopolysaccharides trigger the immune system to produce proinflammatory cytokines IL-1, IL-6, and tumor necrosis factor (TNF) ... psychosocial stress enhances the ability of an immune response to trigger both inflammation and behavioral sickness ...
LILRB3
... The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that ... to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity ...

Famous quotes containing the words innate and/or immune:

    In every one of us there are two ruling and directing principles, whose guidance we follow wherever they may lead; the one being an innate desire of pleasure; the other, an acquired judgment which aspires after excellence.
    Socrates (469–399 B.C.)

    The moral immune system of this country has been weakened and attacked, and the AIDS virus is the perfect metaphor for it. The malignant neglect of the last twelve years has led to breakdown of our country’s immune system, environmentally, culturally, politically, spiritually and physically.
    Barbra Streisand (b. 1942)