Identifiers Symbols HOXA5; HOX1; HOX1.3; HOX1C External IDs OMIM: 142952 MGI: 96177 HomoloGene: 40726 GeneCards: HOXA5 Gene

Gene Ontology
Molecular function DNA binding
sequence-specific DNA binding transcription factor activity
protein binding
sequence-specific DNA binding
Cellular component nucleus
Biological process respiratory system process
transcription, DNA-dependent
anterior/posterior pattern specification
positive regulation of receptor biosynthetic process
cell migration
negative regulation of angiogenesis
thyroid gland development
regulation of mammary gland epithelial cell proliferation
multicellular organism growth
positive regulation of apoptotic process
positive regulation of myeloid cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
embryonic skeletal system morphogenesis
bronchiole development
epithelial tube branching involved in lung morphogenesis
lung goblet cell differentiation
lung-associated mesenchyme development
trachea cartilage morphogenesis
intestinal epithelial cell maturation
mesenchymal-epithelial cell signaling
mammary gland epithelial cell differentiation
mammary gland alveolus development
cell-cell signaling involved in mammary gland development
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3202 15402 Ensembl ENSG00000106004 ENSMUSG00000038253 UniProt P20719 P09021 RefSeq (mRNA) NM_019102 NM_010453 RefSeq (protein) NP_061975 NP_034583 Location (UCSC) Chr 7:
27.18 – 27.18 Mb Chr 6:
52.2 – 52.2 Mb PubMed search

Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.