Homology Modeling - Utility

Utility

Uses of the structural models include protein–protein interaction prediction, protein–protein docking, molecular docking, and functional annotation of genes identified in an organism's genome. Even low-accuracy homology models can be useful for these purposes, because their inaccuracies tend to be located in the loops on the protein surface, which are normally more variable even between closely related proteins. The functional regions of the protein, especially its active site, tend to be more highly conserved and thus more accurately modeled.

Homology models can also be used to identify subtle differences between related proteins that have not all been solved structurally. For example, the method was used to identify cation binding sites on the Na+/K+ ATPase and to propose hypotheses about different ATPases' binding affinity. Used in conjunction with molecular dynamics simulations, homology models can also generate hypotheses about the kinetics and dynamics of a protein, as in studies of the ion selectivity of a potassium channel. Large-scale automated modeling of all identified protein-coding regions in a genome has been attempted for the yeast Saccharomyces cerevisiae, resulting in nearly 1000 quality models for proteins whose structures had not yet been determined at the time of the study, and identifying novel relationships between 236 yeast proteins and other previously solved structures.

Read more about this topic:  Homology Modeling

Other articles related to "utility":

Utility - Discussion and Criticism
... Joan Robinson famously criticized utility for being a circular concept "Utility is the quality in commodities that makes individuals want to buy them, and the fact that individuals ... Another criticism comes from the assertion that neither cardinal nor ordinary utility is empirically observable in the real world ... In the case of cardinal utility it is impossible to measure the level of satisfaction "quantitatively" when someone consumes or purchases an apple ...
Friedman–Savage Utility Function - Additions
... a former student of Friedman's, argued that some of the implications of the Friedman–Savage utility function were paradoxical ... His solution was to relate the curvature of an individual's utility function to increases in wealth ... This involved determining an individual's "normal" level of income, controlling for utility gains from "recreational investments" (The psychological utility ...

Famous quotes containing the word utility:

    Moral sensibilities are nowadays at such cross-purposes that to one man a morality is proved by its utility, while to another its utility refutes it.
    Friedrich Nietzsche (1844–1900)