HMGB1 - Interactions - Interaction Via TLR4

Interaction Via TLR4

Among the receptors of amphoterin includes toll-like receptors. Interaction of HMGB1 and TLR4 results in upregulation of NF-kappa B, which leads to increased production and an release of cytokines in macrophages and in neutrophils for example stimulates release ROS via TLR-dependent activation of NADPH oxidase. HMGB1-LPS complex activates TLR4, and leads to binding adapter proteins (MyD88 and others), which leads to signal transduction and activate signaling cascades. In the last line leads to activation of MAPK cascades and NF-kapa B and thus to the production of cytokines and other inflammatory molecules.

Read more about this topic:  HMGB1, Interactions

Famous quotes containing the word interaction:

    Here is this vast, savage, howling mother of ours, Nature, lying all around, with such beauty, and such affection for her children, as the leopard; and yet we are so early weaned from her breast to society, to that culture which is exclusively an interaction of man on man,—a sort of breeding in and in, which produces at most a merely English nobility, a civilization destined to have a speedy limit.
    Henry David Thoreau (1817–1862)