HLA-DQB1

HLA-DQB1

Identifiers Symbols HLA-DQB1; CELIAC1; HLA-DQB; IDDM1 External IDs OMIM: 604305 HomoloGene: 1603 GeneCards: HLA-DQB1 Gene

Gene Ontology
Molecular function MHC class II receptor activity
Cellular component Golgi membrane
lysosomal membrane
plasma membrane
endosome membrane
ER to Golgi transport vesicle membrane
membrane
transport vesicle membrane
endocytic vesicle membrane
clathrin-coated endocytic vesicle membrane
trans-Golgi network membrane
MHC class II protein complex
integral to lumenal side of endoplasmic reticulum membrane
Biological process immunoglobulin production involved in immunoglobulin mediated immune response
humoral immune response mediated by circulating immunoglobulin
immune response
cytokine-mediated signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell costimulation
T cell receptor signaling pathway
interferon-gamma-mediated signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3119 14961 Ensembl ENSG00000179344 ENSMUSG00000073421 UniProt P01920 P14483 RefSeq (mRNA) NM_001243961 NM_207105 RefSeq (protein) NP_001230890 NP_996988 Location (UCSC) Chr 6:
32.63 – 32.64 Mb Chr 17:
34.26 – 34.27 Mb PubMed search

Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic locus that contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

Read more about HLA-DQB1:  Function, Gene Structure and Polymorphisms, Alleles

Other related articles:

HLA-DQB1 - Alleles
... HLA-DQB1 alleles Serotype DQB1 allele DQ2 *0201 *0202 *0203 DQ4 *0401 *0402 DQ5 *0501 *0502 *0503 *0504 DQ6 *0601 *0602 *0603 *0604 *0605 *0609 DQ7 *0301 ...