HER2/neu

HER2/neu

Identifiers Symbols ERBB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1 External IDs OMIM: 164870 MGI: 95410 HomoloGene: 3273 ChEMBL: 1824 GeneCards: ERBB2 Gene EC number 2.7.10.1

Gene Ontology
Molecular function RNA polymerase I core binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane signaling receptor activity
epidermal growth factor-activated receptor activity
protein binding
ATP binding
protein C-terminus binding
growth factor binding
protein phosphatase binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
protein dimerization activity
Cellular component nucleus
plasma membrane
endosome membrane
integral to membrane
basolateral plasma membrane
receptor complex
perinuclear region of cytoplasm
Biological process positive regulation of protein phosphorylation
transcription, DNA-dependent
protein phosphorylation
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
nervous system development
axon guidance
heart development
cell proliferation
phosphatidylinositol 3-kinase cascade
signal transduction by phosphorylation
positive regulation of cell growth
mammary gland development
positive regulation of Rho GTPase activity
regulation of microtubule-based process
wound healing
positive regulation of MAP kinase activity
positive regulation of translation
regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase III promoter
protein autophosphorylation
phosphatidylinositol-mediated signaling
positive regulation of epithelial cell proliferation
regulation of ERK1 and ERK2 cascade
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2064 13866 Ensembl ENSG00000141736 ENSMUSG00000062312 UniProt P04626 P70424 RefSeq (mRNA) NM_001005862.1 NM_001003817.1 RefSeq (protein) NP_001005862.1 NP_001003817.1 Location (UCSC) Chr 17:
37.84 – 37.89 Mb Chr 11:
98.41 – 98.44 Mb PubMed search

HER2 (Human Epidermal Growth Factor Receptor 2) also known as Neu, ErbB-2, CD340 (cluster of differentiation 340) or p185 is a protein that in humans is encoded by the ERBB2 gene. HER2 is a member of the epidermal growth factor receptor (EGFR/ErbB) family. Amplification or over-expression of this gene has been shown to play an important role in the pathogenesis and progression of certain aggressive types of breast cancer and in recent years it has evolved to become an important biomarker and target of therapy for the disease.

Read more about HER2/neu:  HER2 and Cancer, Drugs Targeting HER2, HER2 Testing, HER2 Interactions