GP1BA

GP1BA

Identifiers Symbols GP1BA; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GPIbA; VWDP External IDs OMIM: 606672 MGI: 1333744 HomoloGene: 143 GeneCards: GP1BA Gene

Gene Ontology
Molecular function protein binding
thrombin receptor activity
Cellular component plasma membrane
integral to plasma membrane
membrane
anchored to external side of plasma membrane
Biological process cell morphogenesis
cell adhesion
cell surface receptor signaling pathway
blood coagulation
blood coagulation, intrinsic pathway
platelet activation
regulation of blood coagulation
fibrinolysis
thrombin receptor signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2811 14723 Ensembl ENSG00000185245 ENSMUSG00000050675 UniProt P07359 O35930 RefSeq (mRNA) NM_000173 NM_010326 RefSeq (protein) NP_000164 NP_034456 Location (UCSC) Chr 17:
4.84 – 4.84 Mb Chr 11:
70.64 – 70.64 Mb PubMed search

Glycoprotein Ib (platelet), alpha polypeptide (GP1BA) also known as CD42b (Cluster of Differentiation 42b), is a human gene.

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Read more about GP1BA:  Interactions

Other articles related to "gp1ba":

GP1BA - Interactions
... GP1BA has been shown to interact with YWHAZ and FLNB. ...