|Molecular function||• protein binding
• thrombin receptor activity
|Cellular component||• plasma membrane
• integral to plasma membrane
• anchored to external side of plasma membrane
|Biological process||• cell morphogenesis
• cell adhesion
• cell surface receptor signaling pathway
• blood coagulation
• blood coagulation, intrinsic pathway
• platelet activation
• regulation of blood coagulation
• thrombin receptor signaling pathway
|Sources: Amigo / QuickGO|
4.84 – 4.84 Mb
70.64 – 70.64 Mb
Glycoprotein Ib (platelet), alpha polypeptide (GP1BA) also known as CD42b (Cluster of Differentiation 42b), is a human gene.
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Read more about GP1BA: Interactions
Other articles related to "gp1ba":
... GP1BA has been shown to interact with YWHAZ and FLNB. ...