Fucose

Fucose is a hexose deoxy sugar with the chemical formula C6H12O5. It is found on N-linked glycans on the mammalian, insect and plant cell surface, and is the fundamental sub-unit of the fucoidan polysaccharide. α(1→3) linked core fucose is a suspected carbohydrate antigen for IgE-mediated allergy.

Two structural features distinguish fucose from other six-carbon sugars present in mammals: the lack of a hydroxyl group on the carbon at the 6-position (C-6) and the -configuration. It is equivalent to 6-deoxy--galactose.

In the fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an attachment point for adding other sugars. In human N-linked glycans, fucose is most commonly linked α-1,6 to the reducing terminal β-N-acetylglucosamine. However, fucose at the non-reducing termini linked α-1,2 to galactose forms the H antigen, the substructure of the A and B blood group antigens.

Fucose is metabolized by an enzyme called α-fucosidase.

L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements.

Other articles related to "fucose":

Glycoprotein 3-alpha-L-fucosyltransferase
... is an enzyme that catalyzes the chemical reaction GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)--beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N ... The systematic name of this enzyme class is GDP-L-fucoseglycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)--beta-D-ma ... GDP-L-fucoseglycoprotein (L-fucose to asparagine-linked, N-acetylglucosamine of, 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)--beta ...
GDP-L-fucose Synthase
... In enzymology, a GDP-L-fucose synthase (EC 1.1.1.271) is an enzyme that catalyzes the chemical reaction GDP-L-fucose + NADP+ GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ Thus ...
L-fucose Isomerase
... In enzymology, a L-fucose isomerase (EC 5.3.1.25) is an enzyme that catalyzes the chemical reaction L-fucose L-fuculose Hence, this enzyme has one substrate, L-fucose, and one product, L-fuculose ... The systematic name of this enzyme class is L-fucose aldose-ketose-isomerase ...
FPGT
... Fucose-1-phosphate guanylyltransferase is an enzyme that in humans is encoded by the FPGT gene ... L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in ... donor for these fucosylated oligosaccharides is GDP-beta-L-fucose ...