FKBP1A

FKBP1A

Identifiers Symbols FKBP1A; FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE External IDs OMIM: 186945 MGI: 95541 HomoloGene: 105139 ChEMBL: 1902 GeneCards: FKBP1A Gene EC number 5.2.1.8

Gene Ontology
Molecular function peptidyl-prolyl cis-trans isomerase activity
signal transducer activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor binding
ryanodine-sensitive calcium-release channel activity
protein binding
macrolide binding
FK506 binding
type I transforming growth factor beta receptor binding
ion channel binding
SMAD binding
activin binding
Cellular component cytosol
terminal cisterna
axon
sarcoplasmic reticulum membrane
Biological process protein peptidyl-prolyl isomerization
heart morphogenesis
protein folding
'de novo' protein folding
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
peptidyl-proline modification
protein maturation by protein folding
positive regulation of protein ubiquitination
positive regulation of protein binding
negative regulation of protein phosphatase type 2B activity
regulation of activin receptor signaling pathway
beta-amyloid formation
protein refolding
T cell activation
positive regulation of I-kappaB kinase/NF-kappaB cascade
extracellular fibril organization
regulation of immune response
ventricular cardiac muscle tissue morphogenesis
regulation of ryanodine-sensitive calcium-release channel activity
heart trabecula formation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2280 14225 Ensembl ENSG00000088832 ENSMUSG00000032966 UniProt P62942 P26883 RefSeq (mRNA) NM_000801 NM_008019 RefSeq (protein) NP_000792 NP_032045 Location (UCSC) Chr 20:
1.35 – 1.37 Mb Chr 2:
151.54 – 151.56 Mb PubMed search

Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the FKBP1A gene.

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. There is evidence of multiple alternatively spliced transcript variants for this gene, but the full length nature of some variants has not been determined.

Read more about FKBP1A:  Interactions

Other articles related to "fkbp1a":

FKBP1A - Interactions
... FKBP1A has been shown to interact with RYR1, Mammalian target of rapamycin, TGF beta receptor 1, GLMN, ITPR1 and KIAA1303 ...