Identifiers Symbols FGF7; HBGF-7; KGF External IDs OMIM: 148180 MGI: 95521 HomoloGene: 7316 GeneCards: FGF7 Gene

Gene Ontology
Molecular function type 2 fibroblast growth factor receptor binding
protein binding
growth factor activity
heparin binding
chemoattractant activity
Cellular component extracellular region
extracellular space
Golgi apparatus
Biological process ovarian follicle development
phosphatidylcholine biosynthetic process
signal transduction
positive regulation of cell proliferation
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
epidermis development
response to wounding
mesenchymal cell proliferation
positive regulation of keratinocyte proliferation
hair follicle morphogenesis
actin cytoskeleton reorganization
protein localization to cell surface
wound healing
surfactant homeostasis
positive regulation of epithelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of keratinocyte migration
positive regulation of cell division
branching involved in salivary gland morphogenesis
positive regulation of epithelial cell proliferation involved in lung morphogenesis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
secretion by lung epithelial cell involved in lung growth
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2252 14178 Ensembl ENSG00000140285 ENSMUSG00000027208 UniProt P21781 P36363 RefSeq (mRNA) NM_002009 NM_008008 RefSeq (protein) NP_002000 NP_032034 Location (UCSC) Chr 15:
49.72 – 50.15 Mb Chr 2:
126.03 – 126.09 Mb PubMed search

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.

Read more about FGF7:  Interactions

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FGF7 - Interactions
... FGF7 has been shown to interact with Perlecan. ...