FABP7

FABP7

Identifiers Symbols FABP7; B-FABP; BLBP; FABPB; MRG External IDs OMIM: 602965 MGI: 101916 HomoloGene: 37880 GeneCards: FABP7 Gene

Gene Ontology
Molecular function transporter activity
lipid binding
Cellular component nucleus
cytoplasm
cell projection
neuronal cell body
Biological process nervous system development
negative regulation of cell proliferation
cell proliferation in forebrain
neurogenesis
epithelial cell proliferation
prepulse inhibition
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2173 12140 Ensembl ENSG00000164434 ENSMUSG00000019874 UniProt O15540 P51880 RefSeq (mRNA) NM_001446 NM_021272 RefSeq (protein) NP_001437 NP_067247 Location (UCSC) Chr 6:
123.1 – 123.11 Mb Chr 10:
57.78 – 57.79 Mb PubMed search

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene. The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors. Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.

Read more about FABP7:  Role in Pathology

Other articles related to "fabp7":

FABP7 - Role in Pathology
... FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis ... As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia, with one, that tested for only one SNP, showing negative and another ... This study also linked FABP7 variation to weak prepulse inhibition in mice deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives ...