ERBB4

ERBB4

Identifiers Symbols ERBB4; HER4; p180erbB4 External IDs OMIM: 600543 MGI: 104771 HomoloGene: 21084 ChEMBL: 3009 GeneCards: ERBB4 Gene EC number 2.7.10.1

Gene Ontology
Molecular function protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
epidermal growth factor receptor binding
protein binding
ATP binding
protein homodimerization activity
transcription regulatory region DNA binding
Cellular component extracellular region
nucleus
nucleoplasm
nucleolus
cytoplasm
mitochondrion
mitochondrial matrix
cytosol
plasma membrane
caveola
postsynaptic density
integral to membrane
basolateral plasma membrane
Biological process neural crest cell migration
positive regulation of protein phosphorylation
transcription, DNA-dependent
apoptotic process
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
heart development
lactation
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
embryonic pattern specification
cell migration
peptidyl-tyrosine phosphorylation
central nervous system morphogenesis
olfactory bulb interneuron differentiation
regulation of cell migration
positive regulation of cell migration
positive regulation of synaptic transmission, GABAergic
response to progesterone stimulus
response to drug
positive regulation of tyrosine phosphorylation of Stat5 protein
response to hydrogen peroxide
negative regulation of apoptotic process
surfactant homeostasis
positive regulation of phosphatidylinositol 3-kinase activity
cell fate commitment
positive regulation of transcription, DNA-dependent
positive regulation of glucose import
protein autophosphorylation
positive regulation of epithelial cell proliferation
positive regulation of cardiac muscle cell proliferation
synapse maturation
mammary gland epithelial cell differentiation
mammary gland alveolus development
cardiac muscle tissue regeneration
positive regulation of ERK1 and ERK2 cascade
positive regulation of STAT protein import into nucleus
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2066 13869 Ensembl ENSG00000178568 ENSMUSG00000062209 UniProt Q15303 Q61527 RefSeq (mRNA) NM_001042599 NM_010154 RefSeq (protein) NP_001036064 NP_034284 Location (UCSC) Chr 2:
212.24 – 213.4 Mb Chr 1:
68.03 – 69.11 Mb PubMed search

Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.

Read more about ERBB4:  Function, Clinical Significance, Interactions

Other articles related to "erbb4":

ERBB4 - Interactions
... ERBB4 has been shown to interact with DLG4 NRG1, STAT5A, and YAP1. ...