ERBB3

ERBB3

Identifiers Symbols ERBB3; ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3 External IDs OMIM: 190151 MGI: 95411 HomoloGene: 20457 ChEMBL: 5838 GeneCards: ERBB3 Gene EC number 2.7.10.1

Gene Ontology
Molecular function protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
protein binding
ATP binding
growth factor binding
protein tyrosine kinase activator activity
protein homodimerization activity
protein heterodimerization activity
Cellular component extracellular space
nucleus
plasma membrane
integral to plasma membrane
basolateral plasma membrane
apical plasma membrane
lateral plasma membrane
receptor complex
postsynaptic membrane
Biological process endocardial cushion development
negative regulation of cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
axonogenesis
peripheral nervous system development
heart development
skeletal muscle tissue development
circadian rhythm
negative regulation of signal transduction
Schwann cell differentiation
phosphatidylinositol 3-kinase cascade
positive regulation of phosphatidylinositol 3-kinase cascade
cranial nerve development
cellular response to insulin stimulus
wound healing
regulation of cell proliferation
odontogenesis
response to drug
negative regulation of neuron apoptotic process
tongue development
positive regulation of glucose import
negative regulation of secretion
neuron apoptotic process
mammary gland involution
positive regulation of protein tyrosine kinase activity
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2065 13867 Ensembl ENSG00000065361 ENSMUSG00000018166 UniProt P21860 Q61526 RefSeq (mRNA) NM_001005915 NM_010153 RefSeq (protein) NP_001005915 NP_034283 Location (UCSC) Chr 12:
56.47 – 56.5 Mb Chr 10:
128.57 – 128.59 Mb PubMed search

Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene.

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intramembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

It is thought that ERBB3, when activated, becomes a substrate for dimerization and subsequent phosphorylation by ERBB1, ERBB2 and ERBB4.

Like many of the receptor tyrosine-kinases, ERBB3 is activated by extracellular ligand. Ligands known to bind to ERBB3 include heregulin.

Read more about ERBB3:  Interactions

Other articles related to "erbb3":

ERBB3 - Interactions
... ERBB3 has been shown to interact with Neuregulin 1, PA2G4, PIK3R1 and RGS4. ...