Enolase

Enolase, also known as phosphopyruvate hydratase, is a metalloenzyme responsible for the catalysis of the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. Enolase belongs to the class Lyase. Enolase can also catalyze the reverse reaction, depending on environmental concentrations of substrates. The optimum pH for this enzyme is 6.5. Enolase is present in all tissues and organisms capable of glycolysis or fermentation. The enzyme was discovered by Lohmann and Meyerhof in 1934, and has since been isolated from a variety of sources including human muscle and erythrocytes.

Read more about EnolaseIsozymes, Structure, Mechanism, Diagnostic Uses, Fluoride Inhibition

Other articles related to "enolase":

Enolase Deficiency - Pathophysiology
... The enolase enzyme catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate this is the ninth step in glycolysis ... Enolase is a dimeric protein formed from three subunits, α, β, and γ, encoded by different genes ... The αα homodimer assumes all enolase activity in the early stages of embryo development and in some adult tissues ...
Alpha-enolase
... UCSC) Chr 1 8.92 – 8.94 Mb Chr 18 48.05 – 48.05 Mb PubMed search Enolase 1, more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most ...
Phosphopyruvate Hydratase
... Other names in common use include enolase, 2-phosphoglycerate dehydratase, 14-3-2-protein, nervous-system specific enolase, phosphoenolpyruvate hydratase, 2-phosphoglycerate dehydratase, 2-phosphoglyceri ...
Enolase 2
... Location (UCSC) Chr 12 7.02 – 7.03 Mb Chr 6 124.76 – 124.77 Mb PubMed search Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded ... Gamma-enolase is a phosphopyruvate hydratase ... Gamma-enolase is one of the three enolase isoenzymes found in mammals ...
Enolase - Fluoride Inhibition
... Fluoride is a known competitor of enolase’s substrate 2-PG ... water provides fluoride at a level that inhibits oral bacteria enolase activity without harming humans ...