Disorders of Calcium Metabolism - Hypercalcemia

Hypercalcemia

Hypercalcemia is suspected to occur in approximately 1 in 500 adults in the general adult population. Like hypocalcemia, hypercalcemia can be non-severe and present with no symptoms, or it may be severe, with life-threatening symptoms. Hypercalcemia is most commonly caused by hyperparathyroidism and by malignancy, and less commonly by vitamin D intoxication, familial hypocalciuric hypercalcemia and by sarcoidosis. Hyperparathyroidism occurs most commonly in postmenopausal women. Hyperparathyroidism can be caused by a tumor, or adenoma, in the parathyroid gland or by increased levels of parathyroid hormone due to hypocalcemia. Approximately 10% of cancer sufferers experience hypercalcemia due to malignancy. Hypercalcemia occurs most commonly in breast cancer, lymphoma, prostate cancer, thyroid cancer, lung cancer, myeloma, and colon cancer. It may be caused by secretion of parathyroid hormone-related peptide by the tumor (which has the same action as parathyroid hormone), or may be a result of direct invasion of the bone, causing calcium release. Symptoms of hypercalcemia include anorexia, nausea, vomiting, constipation, abdominal pain, lethargy, depression, confusion, polyuria, polydipsia and generalized aches and pains.

Read more about this topic:  Disorders Of Calcium Metabolism

Other articles related to "hypercalcemia":

Differential Diagnosis - Specific Methods - By Epidemiology - Example
... above the standard reference range, which, by most definitions, classifies as hypercalcemia, which becomes the "presentation" in this case ... abbreviated as PH), which may explain the finding of hypercalcemia ... perform a differential diagnostic procedure for the finding of hypercalcemia ...
Familial Hypocalciuric Hypercalcemia
... Familial hypocalciuric hypercalcemia is a condition that can cause hypercalcemia, a serum calcium level typically above 10.2 mg/dL ... is also known as familial benign hypocalciuric hypercalcemia (FBHH) where there is usually a family history of hypercalcemia which is mild, a urine calcium to creatinine ratio ...
Calcium-sensing Receptor - Pathology
... Mutations that inactivate a CaSR gene cause Familial hypocalciuric hypercalcemia (FHH) (also known as Familial Benign Hypercalcemia because it is generally asymptomatic and does not require treatment), when present in ... for CaSR inactivating mutations have more severe hypercalcemia ...
Primary Hyperparathyroidism - Signs and Symptoms
... The signs and symptoms of primary hyperparathyroidism are those of hypercalcemia ... Hypercalcemia can lead to peptic ulcers and acute pancreatitis ... The peptic ulcers can be an effect of increased gastric acid secretion by hypercalcemia, but may also be part of a multiple endocrine neoplasia type 1 ...
Lymphoma In Animals - Lymphoma in Dogs - Signs and Symptoms
... Lymphoma is the most common cancerous cause of hypercalcemia (high blood calcium levels) in dogs ... Hypercalcemia in these cases is caused by secretion of parathyroid hormone-related protein ... Hypercalcemia is most commonly associated with this type ...