Cognitive Informatics - Research Methods - Brain Imaging

Brain Imaging

Brain imaging involves analyzing activity within the brain while performing various tasks. This allows us to link behavior and brain function to help understand how information is processed. Different types of imaging techniques vary in their temporal (time-based) and spatial (location-based) resolution. Brain imaging is often used in cognitive neuroscience.

  • Single photon emission computed tomography and Positron emission tomography. SPECT and PET use radioactive isotopes, which are injected into the subject's bloodstream and taken up by the brain. By observing which areas of the brain take up the radioactive isotope, we can see which areas of the brain are more active than other areas. PET has similar spatial resolution to fMRI, but it has extremely poor temporal resolution.
  • Electroencephalography. EEG measures the electrical fields generated by large populations of neurons in the cortex by placing a series of electrodes on the scalp of the subject. This technique has an extremely high temporal resolution, but a relatively poor spatial resolution.
  • Functional magnetic resonance imaging. fMRI measures the relative amount of oxygenated blood flowing to different parts of the brain. More oxygenated blood in a particular region is assumed to correlate with an increase in neural activity in that part of the brain. This allows us to localize particular functions within different brain regions. fMRI has moderate spatial and temporal resolution.
  • Optical imaging. This technique uses infrared transmitters and receivers to measure the amount of light reflectance by blood near different areas of the brain. Since oxygenated and deoxygenated blood reflects light by different amounts, we can study which areas are more active (i.e., those that have more oxygenated blood). Optical imaging has moderate temporal resolution, but poor spatial resolution. It also has the advantage that it is extremely safe and can be used to study infants' brains.
  • Magnetoencephalography. MEG measures magnetic fields resulting from cortical activity. It is similar to EEG, except that it has improved spatial resolution since the magnetic fields it measures are not as blurred or attenuated by the scalp, meninges and so forth as the electrical activity measured in EEG is. MEG uses SQUID sensors to detect tiny magnetic fields.

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Luciano Fadiga
... humans (transcranial magnetic stimulation, study of spinal excitability, brain imaging, recording of single neurons in awake neurosurgery patients) ... (Experimental Brian Research, 1992 Brain, 1996 Cognitive Brain Research, 1996) ... activated by action observation (by several brain imaging experiments carried out in collaboration with San Raffaele Hospital of Milan, USC and UCLA ...
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