Chuk

Chuk

Identifiers Symbols CHUK; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16 External IDs OMIM: 600664 MGI: 99484 HomoloGene: 979 ChEMBL: 3476 GeneCards: CHUK Gene EC number 2.7.11.10

Gene Ontology
Molecular function protein kinase activity
protein binding
ATP binding
IkappaB kinase activity
identical protein binding
Cellular component nucleus
nucleolus
cytoplasm
cytosol
IkappaB kinase complex
internal side of plasma membrane
CD40 receptor complex
intracellular membrane-bounded organelle
Biological process morphogenesis of an epithelial sheet
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
protein phosphorylation
inflammatory response
immune response
epidermal growth factor receptor signaling pathway
I-kappaB kinase/NF-kappaB cascade
I-kappaB phosphorylation
lactation
Toll signaling pathway
fibroblast growth factor receptor signaling pathway
response to virus
anatomical structure morphogenesis
osteoclast differentiation
positive regulation of type I interferon production
mammary gland epithelial cell proliferation
toll-like receptor 1 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB cascade
innate immune response
nerve growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
mammary gland alveolus development
nucleotide-binding oligomerization domain containing signaling pathway
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1147 12675 Ensembl ENSG00000213341 ENSMUSG00000025199 UniProt O15111 Q60680 RefSeq (mRNA) NM_001278 NM_001162410 RefSeq (protein) NP_001269 NP_001155882 Location (UCSC) Chr 10:
101.95 – 101.99 Mb Chr 19:
44.07 – 44.11 Mb PubMed search

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.

Read more about Chuk:  Clinical Significance, Interactions

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