Cannabinoid Receptor - Physiology - Bone


The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.

Read more about this topic:  Cannabinoid Receptor, Physiology

Other articles related to "bone, bones":

Morphometrics - Applications - Bone Histomorphometry
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Osteoimmunology - Crosstalk
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Bone - Terminology
... Several terms are used to refer to features and components of bones throughout the body Bone feature Definition articular process A projection that contacts an adjacent bone ... articulation The region where adjacent bones contact each other — a joint ... foramen An opening through a bone ...
... This bone, collected in 1893, was first identified as the thighbone of a crocodilian, but was described in 1903 by Samuel Wendell Williston as belonging to a pterosaur ... Western Interior Seaway (including the Kiowa Shale) identifies the bone as more likely the upper part of a plesiosaurian propodial (a limb bone) ...

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