The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Other articles related to "bone, bones":
... Histomorphometry of bone involves obtaining a bone biopsy specimen and processing of bone specimens in the laboratory, obtaining estimates of the proportional volumes and surfaces occupied by ... Obtaining a bone biopsy is accomplished by using a bone biopsy trephine ...
... The bone marrow cavity is important for the proper development of the immune system, and houses important stem cells for maintenance of the immune system ... cytokines produced by immune cells also have important effects on regulating bone homeostasis ... the differentiation and activity of osteoclasts and bone resorption ...
... Several terms are used to refer to features and components of bones throughout the body Bone feature Definition articular process A projection that contacts an adjacent bone ... articulation The region where adjacent bones contact each other — a joint ... foramen An opening through a bone ...
... This bone, collected in 1893, was first identified as the thighbone of a crocodilian, but was described in 1903 by Samuel Wendell Williston as belonging to a pterosaur ... Western Interior Seaway (including the Kiowa Shale) identifies the bone as more likely the upper part of a plesiosaurian propodial (a limb bone) ...
Famous quotes containing the word bone:
“You must be wise, in order to sniff out and weigh these mighty books, and swift in the hunt and brave in the battle; then, by careful reading and frequent reflection, crack open the bone and suck out the substantific marrow.”
—François Rabelais (14941553)
“Take adultery or theft.
It is evil who dines on the soul,
stretching out its long bone tongue.
It is evil who tweezers my heart,
picking out its atomic worms.”
—Anne Sexton (19281974)
“the bone dry voices of the peepers
as they throb like advertisements.”
—Anne Sexton (19281974)